国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2011, Vol. 30 ›› Issue (1): 65-68.

• 综述 • 上一篇    下一篇

颗粒细胞增殖分化中卵泡刺激素的 cAMP-PKA通路

陈悦群,黄荷凤   

  1. 310006 杭州，浙江大学医学院附属妇产科医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-01-15 发布日期:2011-01-15

cAMP/PKA Pathway in FSH-Induced Granulosa Cells Proliferation and Differentiation

CHEN Yue-qun， HUANG He-feng   

  1. Woman’s Hospital，School of Medicine，Zhejiang University，Hangzhou 310006，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-01-15 Online:2011-01-15

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摘要： 卵泡刺激素（FSH）是一种重要的女性生殖激素，是由垂体前叶合成和分泌的一种糖蛋白
激素。FSH与卵巢颗粒细胞膜上的特异性受体结合发挥生物学效应。卵泡刺激素受体（FSHR）属于G 蛋白
耦联受体超家族，与FSH 结合后激活环磷酸腺苷（cAMP）/ 蛋白激酶A（PKA）通路下游区信号级联放大，
促进颗粒细胞增殖分化和卵巢性激素的合成。

关键词: 卵泡刺激素, cAMP鄄PKA 通路, 颗粒细胞, 环AMP依赖性蛋白激酶类

Abstract: Follicule鄄stimulating hormone（FSH）is the central hormone of female reproduction. This
gonadotropin is produced and secreted by the anterior pituitary gland as a glycoprotein. FSH evokes its
biological effects by interacting with a high affinity receptor（R）located on the plasma membrane of granulosa
cells in the ovary. The FSH receptor（FSHR）is a glycoprotein that belongs to the superfamily of G protein鄄
coupled receptors（GPCRs），and occupancy of the FSHR causes activation of signaling cascade downstream of
cAMP/PKA pathway. FSH can promote proliferation and differentiation of granulosa cells and synthesis of
sexual hormone.

Key words: Follicule stimulating hormone, cAMP/PKA pathway, Granulosa cells, Cyclic AMP鄄 dependent protein kinases