国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2011, Vol. 30 ›› Issue (1): 69-72.

• 综述 • 上一篇    

槲皮素药理作用在雌激素相关性疾病中的研究进展

杨英,曹阳,张婷婷,朱焰,曹霖   

  1. 200437 上海市中医药大学附属中西医结合岳阳医院 （杨英，曹阳，张婷婷）；上海市计划生育科学研究所（朱焰，曹霖）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-01-15 发布日期:2011-01-15
  • 通讯作者: 张婷婷

The Pharmacologic Actions Progression of Quercetin on Estrogen Related Diseases

YANG Ying, CAO Yang, ZHANG Ting-ting, ZHU Yan, CAO Lin   

  1. The Yueyang Hospital of Shanghai University of TCM, Shanghai 200437, China （YANG Ying, CAO Yang, ZHANG Ting鄄ting）; Shanghai Institute of Planned Parenthood Research，Shanghai 200032, China（ZHU Yan, CAO Lin）
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-01-15 Online:2011-01-15
  • Contact: ZHANG Ting-ting,

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摘要： 槲皮素是一种黄酮类植物雌激素。近年来，有关槲皮素的研究很多，其中在雌激素相关
性疾病研究最多,主要包括乳腺癌、骨质疏松、前列腺癌、宫颈癌等疾病。在这些疾病研究中，槲皮素主要表
现为诱导肿瘤细胞凋亡，调节破骨细胞分化，调控体内雌激素代谢，对肿瘤黏附、侵袭、血管形成各过程都
有影响。与其他黄酮类药物药理作用相比，槲皮素有其独特性。槲皮素在雌激素相关性疾病中的作用机制
呈多元化，大体概括为两方面：①抗氧化作用，诱导细胞凋亡，调控雌激素代谢。②雌激素受体（ER）调节作
用，调控ER 下游许多底物及信号通路。

关键词: 槲皮素, 雌激素类, 受体, 雌激素, 抗氧化剂

Abstract: Quercetin is one of flavones in phytoestrogen .Recently ,there have many researches about
quercetin, and most of them are related with estrogen correlative diseases,such as breast cancer , osteoporosis
and prostate cancer, et al. In these diseases, there may have many effects, including promoting cell apoptosis ,
controlling osteoclasts differentiation,regulation estrogen metabolism in vivo and effecting tumor cell growth
progression ,involving adhesion ,invasion and angiopoiesis .Comparing with other flavones ,quercetin has its
own distinct character. Many mechanisms may explain quercetin pharmacologic actions, mainly to sum up for
two aspests: 淤Expression of antioxidation: inducing cell apoptosis and regulating estrogen metabolism. 于
Regulation of estrogens: as a estrogen receptor (ER) modulator,quercetin restrains tumor cell growth by
influencing down鄄stream substrate of ER and impacting signal pathway

Key words: QUERCETIN, Estrogens, Receptors, estrogen, Antioxidants