国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2011, Vol. 30 ›› Issue (4): 291-292.

• 综述 • 上一篇    下一篇

空卵泡综合征：一种存在争议的综合征

陈 媛, 乔 杰   

  1. 100191 北京大学第三医院生殖医学中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-07-15 发布日期:2011-07-15

Comment on Empty Follicle Syndrome：A Controversial Issue

CHEN Yuan, QIAO Jie   

  1. Jie. Reproductive Medicine Center, Peking University Third Hospital, Beijing 100191, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-07-15 Online:2011-07-15

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摘要： 空卵泡综合征（EFS）是辅助生殖技术（ART）中一种罕见而棘手的疾病，一旦发生将有可能导致该治疗周期提前结束。根据不同的发病原因分为真性空卵泡综合征和假性空卵泡综合征。发病机制至今尚未阐明，可能与人绒毛膜促性腺激素（hCG）有效性降低、卵巢因素、遗传因素或基因突变等有关。空卵泡综合征发病率低，复发率随年龄增长而增加。临床诊断缺乏特异性指标，主要通过排除性、回顾性诊断。治疗困难。假性空卵泡综合征患者通过补救性注射绒毛膜促性腺激素有效。真性空卵泡综合征预后差。

关键词: 绒毛膜促性腺激素, 雌二醇, 预后, 空卵泡综合征

Abstract: Empty follicle syndrome（EFS）， which classified as “genuine” of “false”, is a rare complication of in vitro fertilization（IVF） treatment, leading to cycle cancellation. The underlying mechanism of the EFS remains hypothetical, such as low human chorionic gonadotropin（hCG） bioavailability, ovarian dysfunction and genetic factors. The risk of recurrence is higher as the age of the patients increases. Consequently, the diagnosis of EFS is retrospective while its treatment is difficult. Some false EFS patients could be rescued by repeating the hCG injection on the day of unsuccessful oocyte retrieval. The occurrence of genuine EFS will indicate poor IVF success in subsequent IVF cycles.

Key words: Chorionic gonadotropin, Estradiol, Prognosis, Empty follicle syndrome