国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2012, Vol. 31 ›› Issue (6): 479-483.

• 综述 • 上一篇    下一篇

促性腺激素释放激素激动剂对子宫内膜容受性的调控

杨 婷, 李丽斐, 张学红   

  1. 30000 兰州大学第一医院生殖医学专科医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-11-15 发布日期:2012-11-15

Role of Gonadotropin-releasing Hormone Agonist in Regulation of Endometrium Receptivity

YANG Ting，LI Li-fei，ZHANG Xue-hong   

  1. The Reproductive Medicine Specialized Hospital of the First Hospital of Lanzhou University，Lanzhou 730000，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-11-15 Online:2012-11-15

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摘要： 在辅助生殖技术中，促性腺激素释放激素激动剂（GnRHa）长方案已被广泛应用于超促排卵过程中，GnRHa有效解决了单纯促排卵所致早发的黄体生成激素（LH）峰造成卵子质量下降和周期取消率高的问题。有研究表明超促排卵过程中子宫内膜容受性较自然周期发生改变，总结GnRH-a的生理功能，讨论GnRHa对子宫内膜容受性相关细胞因子（整合素、转化生长因子）、超微结构及颗粒细胞凋亡的影响，探究GnRHa对于内膜内分泌环境和早期胚胎着床的作用，综述新近GnRHa在超促排卵过程中的使用策略，旨在为制定合理科学的GnRHa个体化使用方案提供参考。

关键词: 生殖技术, 辅助, 促性腺素释放激素, 子宫内膜, 整合素类, 转化生长因子β, 胞饮作用, 粒细胞, 细胞凋亡

Abstract: The long GnRH agonist protocol has been widely used during controlled ovarian hyperstimulation （COH） for in vitro fertilization and embryo transfer （IVF-ET）. It is clear that gonadotropin-releasing hormone agonist（GnRHa）was used to prevent the premature LH surge related to worse follicles and higher cancellation rate. GnRHa may affect the endometrium at the molecular level, which may be responsible for endometrial receptivity. Those factors and cytokines related with endometrium receptivity, such as integrinανβ3 and TGF-β, were discussed. Effects of GnRHa on the endometrium ultrastructure and granular cell apoptosis were also discussed. However，the role of GnRHa in endometrial endocrine，embryo invasion，and subsequent pregnancy remains controversial. This review on the GnRHa strategies during COH could help clinicists to design the rational and individual protocol of GnRHa.

Key words: Reproductive techniques, assisted, Gonadotropin-releasing hormone, Endometrium, Integrins, Transforming growth factor beta, Pinocytosis, Granulocytes, Apoptosis