国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2013, Vol. 32 ›› Issue (5): 356-360.

• 综述 • 上一篇    下一篇

绝经后激素替代疗法的个性化药物选择

欧 华,郁 琦   

  1. 100029 北京，中日友好医院（欧 华）；中国医学科学院 北京协和医学院 北京协和医院妇产科（郁 琦）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-09-15 发布日期:2013-09-15
  • 通讯作者: 郁 琦

Individualized Medicine Selection of Postmenopausal Hormone Replacement Therapy

OU Hua，YU Qi   

  1. China-Japan Friendship Hospital，Beijing 100029，China（OU Hua）；Department of Obstetrics and Gynecology，Peking Union Medical College Hospital，Chinese Acadamy of Medical Science & Peking Union Medical College，Beijing 100730，China（YU Qi）
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-09-15 Online:2013-09-15
  • Contact: YU Qi

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摘要：
激素替代疗法（HRT）可以有效缓解女性绝经相关症状，预防绝经后骨质疏松及老年慢性疾病。目前中国有非常庞大的绝经期人口，非常有必要让广大的妇产科医生在临床中给予患者正确的指导。HRT的安全性问题一直备受关注，目前多项临床研究提示，HRT的安全性与启用时机和个体化用药方案有密切关系。HRT应在窗口期开始使用，选择用药方案时应根据患者的年龄、绝经时间、症状侧重点、家族疾病史和基础疾病综合考虑，从而减少不良反应的产生，并且用药期间需规范随诊。

关键词: 绝经期, 激素替代疗法, 骨质疏松, 绝经后, 个性, 窗口期

Abstract: Hormone replacement therapy （HRT） can effectively alleviate those symptoms of female menopausal，and prevent the postmenopausal osteoporosis and some senile chronic diseases. There are a large number of menopausal women in China. It's necessary for most of gynecologists to have an exact recognition on HRT. And for the clinical operation，they should provide the right instruction on HRT for the individual patient. However，both patients and doctors are concerned about safety of HRT. Recent evidences from clinical research showed that the HRT safety was significantly related to the enable timing and individualized dosage regimen. HRT should be started in the window period，while the individualized dosage regimen should be based on the different age，specific symptoms，the family disease history and baseline diseases. The Standardized follow-up is necessary during treatment.

Key words: Menopause, Hormone replacement therapy, Osteoporosis, postmenopausal, Individuality, Window period