国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2013, Vol. 32 ›› Issue (6): 471-474.

• 综述 • 上一篇    下一篇

PTEN与女性生殖

覃 茜,刘冬娥   

  1. 410008 长沙，中南大学湘雅医院生殖医学中心[覃 茜（现在柳州市妇幼保健院）、刘冬娥]
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-11-15 发布日期:2013-11-15
  • 通讯作者: 刘冬娥

PTEN and Female Reproduction

QIN Xi，LIU Dong-e   

  1. Reproductive Medicine Center，Xiangya Hospital of Central South University，Changsha 410008，China [QIN Xi（now working at Liuzhou Maternal and Child Health Care Hospital），LIU Dong-e]
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-11-15 Online:2013-11-15
  • Contact: LIU Dong-e

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摘要： 近年来研究发现，抑癌基因Pten及其编码的PTEN蛋白可能通过磷脂酰肌醇3激酶（PI3K）等通路调控细胞的生长、分化及凋亡。在女性生殖系统中，PTEN通过PTEN-PI3K-3-磷酸肌醇依赖性蛋白激酶-1（PDK1）信号网络，不但控制原始卵泡的生存和激活、颗粒细胞的增殖和分化，影响卵泡的发育、生殖衰老的过程和生殖时间的长短，而且调控子宫内膜的增殖及早期胚胎的着床和发育。

关键词: PTEN磷酸水解酶, 基因, 女(雌)性泌尿生殖系统疾病, 卵泡, 子宫内膜, 胚胎发育

Abstract: Recent studies found that Pten, a tumor suppressor gene, and PTEN protein played an important role in regulating cell growth， differentiation and apoptosis through the PI3K pathway. In the female reproductive system, PTEN plays an important role in regulating follicular development, reproductive aging and years by controlling the survival and activation of primordial follicles， the proliferation and differentiation of granulosa cells though the PTEN-PI3K-PDK1 signaling networks. By the same networks, PTEN regulates the endometrial proliferation, and the implantation and development of early embryo.

Key words: PTEN phosphohydrolase, Genes, Female urogenital diseases, Ovarian follicle, Endometrium, Embryonic development