国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2013, Vol. 32 ›› Issue (6): 506-508.

• 综述 • 上一篇    

HOXA10基因表达对子宫内膜异位症患者胚胎着床的作用

李 萍,蔡 霞   

  1. 830054 乌鲁木齐，新疆医科大学第一附属医院生殖中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-11-15 发布日期:2013-11-15
  • 通讯作者: 蔡 霞

Effect of HOXA10 Gene Expression on Embryonic Implantation in Patients with Endometriosis

LI Ping，CAI Xia   

  1. Reproductive Center, the First Affiliated Hospital of Xinjiang Medical University，Urumqi 830054，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-11-15 Online:2013-11-15
  • Contact: CAI Xia

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摘要： 同源异型盒（HOX）蛋白质是高度保守的转录因子，决定着包括人类在内的许多物种的部分生物性状的表达。HOXA10基因通过调节下游基因及雌激素、孕激素的表达直接影响子宫的胚胎发育和着床。根据体内激素的调控作用，HOXA10基因在子宫内膜上呈周期性表达，其表达高峰发生在植入窗期。HOXA10基因在子宫内膜异位症（EMs）病变中表达对子宫内膜组织的“从头开始”发育过程是必要的。EMs患者的子宫内膜存在影响胚胎着床的诸多不利因素，提示胚胎着床失败可能是EMs患者不孕的主要因素之一。EMs患者通常不会出现HOXA10表达水平在黄体中期上升的现象，可以解释EMs是造成不孕的原因之一。

关键词: 子宫内膜异位症, 不育, 女（雌）性, 同源异型盒A10基因

Abstract: The homebox （HOX） proteins, as the highly conserved transcription factors, determine some body characteristics in many species，including human. HOXA10 is directly involved in the embryogenesis and embryo implantation in uterus by regulating the downstream genes, and estrogen and progesterone levels. In accord with hormones regulation, expression of HOXA10 gene in endometrium has a periodic profile, with the peak expression during the implantation window. Expression of HOXA10 gene in ectopic endometrium is one of important factors related with the “de novo” development of endometrial tissue. There are many factors, which influence embryo implantation, in ectopic endometrium of patients with endometriosis（EMｓ）. It is well known that the embryo implantation failure is one of the main factors of infertility in EMs patients. EMs patients usually do not have the increased expression of HOXA10 in mid-luteal stage, which is one of the reasons of infertility.

Key words: Endometriosis, Infertility, female, HOXA10 gene