国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2014, Vol. 33 ›› Issue (6): 438-442.

• 综述 • 上一篇    下一篇

精子变形中相关蛋白的研究进展

贺忆培，季颖婕，黄敏，丁之德   

  1. 200025 上海交通大学医学院临床医学系2011级八年制（贺忆培，季颖婕，黄敏），解剖学与组织胚胎学系（丁之德）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-11-15 发布日期:2014-11-15
  • 通讯作者: 丁之德

Research Advances in Spermiogenesis-Related Proteins

HE Yi-pei，JI Ying-jie，HUANG Min，DING Zhi-de   

  1. Department of Clinical Medicine，Grade 2011（HE Yi-pei，JI Ying-jie，HUANG Min），Department of Human Anatomy，Histology and Embryology（DING Zhi-de），School of Medicine，Shanghai Jiao Tong University，Shanghai 200025，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-11-15 Online:2014-11-15
  • Contact: DING Zhi-de

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摘要： 精子变形（spermiogenesis）是指精子发生过程中由圆形精细胞转变为蝌蚪形精子的变态过程，同时也是精子发生的最后分化阶段。其过程包括细胞核浓缩、顶体形成、尾部形成、残余体丢失以及短暂出现精子领结构等。近年来，随着基因敲除、表达和功能研究等生物技术的发展和应用，发现了许多与精子变形相关的基因与蛋白，其中有些已被证明在精子变形过程中具有重要作用。综述精子变形的最新进展，包括与精子变形相关的重要蛋白及功能，如高尔基体蛋白、鞭毛相关蛋白、残余体相关蛋白等。

关键词: 精子, 精子发生, 蛋白质类, 顶体

Abstract: Spermiogenesis is the terminal differentiation process during which the round spermatid develops into the tadpole-shaped spermatozoon undergoing morphological changes, including the condensation of spermatid nucleus, the formation of acrosome and tail, the elimination of residual body and the transient appearance of manchette. Recently, with the development and application of new bio-techniques such as gene knockout, gene expression as well as gene functional analysis, many spermiogenesis-related genes and proteins have been unveiled. Some of those proteins were proved to play crucial roles in spermiogenesis. Herein, we reviewed the research advances in spermiogenesis-related proteins, including Golgi apparatus proteins, flagellum-related proteins and residual body-related proteins.

Key words: Spermatozoa, Spermatogenesis, Proteins, Acrosome