核内不均一核糖核蛋白参与卵母细胞发育调控的研究进展

doi:10.12280/gjszjk.20250343

摘要/Abstract

摘要：

核内不均一核糖核蛋白（heterogeneous nuclear ribonucleoprotein，hnRNP）家族包括二十余种在多种生命过程中发挥重要调控作用的RNA结合蛋白。hnRNP的生物学功能丰富，除结合RNA外，主要参与调节N6-甲基腺苷（N6-methyladenosine，m⁶A）修饰和DNA损伤修复等关键生物学过程。多项研究表明，包括HNRNPA2B1、HNRNPC、HNRNPH1和HNRNPK在内的多个hnRNP家族成员在卵母细胞发育过程中发挥重要作用，hnRNP功能缺失可导致卵母细胞发育异常及不孕。然而，目前关于hnRNP调控卵母细胞发育的深入机制研究较少。综述hnRNP的生物学功能及其参与卵母细胞发育调控，为未来生殖领域的研究提供参考。

关键词: 核不均一核糖核蛋白类, RNA结合蛋白质类, 卵子发生, 生殖, 甲基化

Abstract:

The family of heterogeneous nuclear ribonucleoprotein (hnRNP) includes more than twenty kinds of RNA-binding proteins that play an important role in many life processes. Besides RNA binding, hnRNP mainly involved in regulating key biological processes such as N6-methyladenosine (m⁶A) modification and DNA damage repair. Many studies have shown that many members of hnRNP family, including HNRNPA2B1, HNRNPC, HNRNPH1 and HNRNPK, play an important role in the development of oocytes, and that the loss of hnRNP function can lead to the abnormal development of oocytes and infertility. However, the in-depth mechanism reaserch of hnRNP regulating oocyte development is insufficient. Reviewing the biological function of hnRNP in regulating oocyte development can provide reference for future research in reproductive field.

Key words: Heterogeneous-nuclear ribonucleoproteins, RNA-binding proteins, Oogenesis, Reproduction, Methylation

肖锦鑫, 熊孟能, 谢青贞. 核内不均一核糖核蛋白参与卵母细胞发育调控的研究进展[J]. 国际生殖健康/计划生育杂志, 2025, 44(6): 486-489.

XIAO Jin-xin, XIONG Meng-neng, XIE Qing-zhen. Heterogeneous Nuclear Ribonucleoprotein in Regulating Oocyte Development[J]. Journal of International Reproductive Health/Family Planning, 2025, 44(6): 486-489.

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