国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2014, Vol. 33 ›› Issue (6): 443-447.

• 综述 • 上一篇    下一篇

雄激素受体与生殖系统肿瘤

郑巳年，傅广波   

  1. 223300 江苏省淮安市，南京医科大学附属淮安第一医院泌尿外科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-11-15 发布日期:2014-11-15
  • 通讯作者: 傅广波

Androgen Receptor and Reproductive Malignancies

ZHENG Si-nian，FU Guang-bo   

  1. Department of Urology，Huai′an First People′s Hospital，Nanjing Medical University，Huai′an 223300，Jiangsu Province，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-11-15 Online:2014-11-15
  • Contact: FU Guang-bo

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摘要： 雄激素通过与雄激素受体（AR）结合，对细胞生长和分化具有重要调控作用。AR是属于细胞核受体超家族的配体依赖性的反式作用子，存在两种亚型：AR-α和AR-β，并广泛分布于正常和病变组织，其中生殖系统肿瘤被认为是雄激素及其受体作用的重要靶组织。AR在生殖系统肿瘤的发生发展及临床诊治方面的作用，引起了学者们越来越多的关注。最近研究表明AR通过各种途径参与生殖系统肿瘤的发生发展过程，以AR作为治疗靶点可能是生殖系统肿瘤治疗的一种新方法。综述雄激素及其受体在生殖系统肿瘤发生发展、指导临床治疗以及预后评估等方面的作用。

关键词: 雄激素类, 受体, 雄激素, 泌尿生殖系统肿瘤

Abstract: Androgens，via the interaction with their receptors，play important roles in the control of cellular growth and differentiation. Androgen receptors（AR） is a member of the superfamily of nuclear receptors, the ligand-dependent transactivators. AR has two subtypes：AR-α and AR-β. AR expressed in numerous target tissues, normal and pathological tissues，such as reproductive malignancies. It has been suggested that AR played important roles in the development of reproductive malignancies by multiple pathways, and that AR may be a new treatment target of those cancers. We hereby reviewed the recent finding on the effects of androgen and AR on the carcinogenesis and development, as well as potential application of AR as a target in treatment of reproductive malignancies.

Key words: Androgens, Receptors, androgen, Urogenital neoplasms