国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2016, Vol. 35 ›› Issue (1): 70-72.

• 综述 • 上一篇    下一篇

慢性子宫内膜炎在体外受精-胚胎移植中的研究进展

包洪初，刘振腾，郝翠芳   

  1. 264000 山东省烟台市，烟台毓璜顶医院生殖医学科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-01-15 发布日期:2016-01-15
  • 通讯作者: 郝翠芳

Research Progress of Chronic Endometritis during IVF-ET

BAO Hong-chu，LIU Zhen-teng，HAO Cui-fang   

  1. Reproductive Medical Center，Yantai Yuhuangding Hospital，Yantai 264000，Shandong Province，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-01-15 Online:2016-01-15
  • Contact: HAO Cui-fang

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摘要： 体外受精-胚胎移植（IVF-ET）周期中常常存在移植优质胚胎后着床率低的问题，这可能与子宫内部环境异常有关。随着宫腔镜诊断治疗技术的普及，研究人员发现部分不孕症妇女宫腔内存在超声和子宫输卵管造影难以明确的微小病变，即慢性子宫内膜炎（chronic endometritis，CE）。CE是子宫内膜的一种持续性炎症，常常没有临床症状或者仅伴有轻微下腹不适、白带增多等，临床上难以确诊。CE与IVF-ET后反复胚胎着床失败有关，其对IVF-ET结局的影响日益受到关注。组织学检查是诊断CE的金标准，抗感染可能是治疗CE的有效手段。

关键词: 受精, 体外, 胚胎移植, 子宫内膜炎, 宫腔镜检查, 胚胎植入

Abstract: Embryo implantation failure is one of major factors related to the clinical outcomes of in vitro fertilization-embryo transfer（IVF-ET）, even if the good-quality embryos were transferred, which may be related with the aberrant endometrial microenvironment. The chronic endometritis（CE）, a subtle lesion and persistent inflammation without clinical symptom or only accompanied by mild disturbances and increased leucorrhea, is found by the widespread hysteroscopy test, which cannot be diagnosed in some infertility women by routine ultrasound and hysteron-salpingography（HSG）. The effect of CE on the clinical outcomes of IVF-ET has widely been paid attention. It was found that CE was associated with the repeated implantation failure after IVF-ET. The histological test is the gold standard for CE diagnosis, and anti-infective therapy could be effective for those patients with CE.

Key words: Fertilization in vitro, Embryo transfer, Endometritis, Hysteroscopy, Embryo implantation