国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2016, Vol. 35 ›› Issue (4): 348-352.

• 综述 • 上一篇    

Krüppel样因子家族在女性生殖系统疾病中的研究进展

黄亚雄，张元珍   

  1. 430071 武汉大学中南医院（黄亚雄，张元珍）；湖北医药学院附属东风医院（黄亚雄）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-07-15 发布日期:2016-07-15
  • 通讯作者: 张元珍

Krüppel-like Factors and Female Reproductive Diseases

HUANG Ya-xiong，ZHANG Yuan-zhen   

  1. Zhongnan Hospital of Wuhan University，Wuhan 430071，China（HUANG Ya-xiong，ZHANG Yuan-zhen）；Dongfeng Hospital Affiliated to Hubei Medical College，Shiyan 442000，Hubei Province，China（HUANG Ya-xiong）
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-07-15 Online:2016-07-15
  • Contact: ZHANG Yuan-zhen

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摘要： 女性生殖系统疾病很大程度上与雌、孕激素及其受体介导信号通路失调所致细胞增殖、凋亡和分化异常有关。这些核受体的精细调控是复杂的，许多核因子参与其中。Krüppel样因子（Krüppel-like factors，KLFs）是一组与真核细胞转录调控密切相关的锌指蛋白，在女性生殖系统中普遍表达，作为类固醇激素反应的共同调控者和整合者。KLF4在子宫内膜异位症（EMs）患者的在位内膜和子宫内膜肿瘤中表达减少。围着床期，KLF5在子宫内膜容受性的形成中起重要作用，与胚胎成功植入有关。KLF6参与胎盘发育和妊娠的维持。KLF9对孕激素受体起正向调节作用，而对雌激素受体起到负向调节作用。KLF11是一种转录抑制因子，具有潜在地抑制子宫肌瘤、EMs异位病灶生长的功能。深入探讨KLFs的生物功能，对认识女性生殖系统疾病的发病机制有重要意义。

关键词: Kruppel样转录因子类, 锌指, 女（雌）性泌尿生殖系统疾病, 子宫内膜

Abstract: The diseases of female reproductive system were partially related to the abnormal cell proliferation, apoptosis and differentiation which is due to the imbalance between estrogen and progesterone, as well as their receptor-related signaling pathways. The complicated regulation of those nuclear receptor-related signaling pathways is mediated by many nuclear factors, such as Krüppel-like factors (KLFs). KLFs are a group of zinc finger proteins, which is closely related to the transcriptional regulation of eukaryotic cells. KLFs are ubiquitously expressed in female reproductive tissues, as the critical co-regulator and integrator of steroid hormone actions. Expression of KLF4 is decreased in the eutopic endometrium in patients with endometriosis (EMs) and in the endometrial cancer tissues. In peri-implantation stage, KLF5 plays an important role in the formation of the receptivity of endometrium which is associated with successful embryos implantation. KLF6 is involved in the development of placenta and the maintenance of pregnancy. KLF9 plays a positive role in the regulation of progesterone receptor and a negative role in the regulation of estrogen receptor. KLF11 as a transcription inhibitor has the potential to inhibit the growth of uterine fibroids and EMs ectopic lesions. It is helpful to study the biological function of KLFs for understanding the pathogenesis of female reproductive diseases.

Key words: Kruppel-like transcription factors, Zinc fingers, Female urogenital diseases, Endometrium