国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2016, Vol. 35 ›› Issue (5): 429-432.

• 综述 • 上一篇    下一篇

长链非编码RNAs与妇科疾病

林典超，陈琼华   

  1. 350005 福州，福建医科大学第一临床医学院（林典超）；厦门大学附属第一医院（陈琼华）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-10-25 发布日期:2016-10-25
  • 通讯作者: 陈琼华

Long Non-coding RNAs and Gynecological Diseases

LIN Dian-chao，CHEN Qiong-hua   

  1. First Clinical Medical College of Fujian Medical University，Fuzhou 350005，China（LIN Dian-chao）；The First Hospital of Xiamen Attached to the Xiamen University，Xiamen 361004，Fujian Province，China（CHEN Qiong-hua）
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-10-25 Online:2016-10-25
  • Contact: CHEN Qiong-hua

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摘要： 长链非编码RNAs（long non-coding RNAs，lncRNAs）是一类长度超过200个核苷酸的功能性分子，不具备编码蛋白的功能，参与表观遗传学的调控、转录及转录后水平的修饰等，是机体生理和病理过程的重要调控者。目前已证实有上千个lncRNA参与到人类或动物的生命活动中，在妇科疾病中（包括宫颈恶性肿瘤、子宫内膜异位症、多囊卵巢综合征、子宫内膜癌、卵巢癌等）也有相关文献报道。随着lncRNA研究的进展，lncRNA将对妇科疾病的三级预防（早发现、早诊断、早治疗）起重要作用。目前，lncRNA的作用机制及其与疾病的关系尚不明确，介绍lncRNA的功能研究进展、lncRNA在各种妇科疾病发生发展中的作用及其在妇科疾病诊疗中的价值。

关键词: 长链非编码RNA, 后成说, 遗传, 子宫内膜异位症, 生殖器疾病, 女（雌）性

Abstract: Long non-coding RNAs (lncRNAs) are a kind of functional RNA molecules with longer than 200 nucleotides. Although lncRNAs have not the protein-coding function, they are involved in epigenetic control, and transcriptional/post-transcriptional modification, suggesting that lncRNAs are key regulators in many pathological and physiological processes. There are thousands of lncRNAs in human and animals, including some reported lncRNAs which are related to gynecological diseases such as cervical cancer, endometriosis, PCOS, endometrial cancer, ovarian cancer and so on. With the development of lncRNA research, lncRNAs will play an important role in the tertiary prevention (early detection, early diagnosis, early treatment) . However, the mechanism of lncRNAs and the relationship with diseases are still unclear. In this review, the research progress on lncRNAs′ function, the pathological and pathophysiological roles in gynecological diseases, and the potential application of lncRNAs in the diagnosis and therapy of gynecological diseases were summarized.

Key words: Long non-coding RNA, Epigenesis, genetic, Endometriosis, Genital diseases, female