国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2016, Vol. 35 ›› Issue (6): 493-497.

• 综述 • 上一篇    下一篇

化疗对卵巢储备功能的影响及相关防治的研究进展

周林燕，张清学   

  1. 510120 广州中山大学孙逸仙纪念医院生殖中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-12-25 发布日期:2016-12-25

Impact of Chemotherapy on Ovarian Reserve and Ovary Protection

ZHOU Lin-yan, ZHANG Qing-xue   

  1. Reproductive Medicine Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-12-25 Online:2016-12-25

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摘要： 卵巢储备功能即卵巢储备，是指卵巢皮质片区存留卵泡生长、发育、形成可受精卵母细胞的数量和质量的潜在能力，反映女性的生育能力。卵巢内皮质区卵泡池的大小决定了卵巢的储备能力，女性自胎儿形成至出生及绝经后，卵巢内的卵泡经历着发生、生长、发育、成熟、凋亡、闭锁直至耗竭的过程。而卵巢产生卵子的能力减弱，卵母细胞质量下降，导致生育能力降低，称为卵巢储备降低。最新的研究发现化疗作为一种医源性因素可通过影响始基卵泡池导致卵巢储备功能下降，甚至卵巢功能早衰。综述近几年化疗对卵巢始基卵泡影响及相关防治的研究进展。

关键词: 卵巢, 卵泡, 药物疗法, 卵巢功能早衰

Abstract: Ovarian reserve refers to the quantity and quality of fertilizable oocytes derived from the remaining follicles in ovarian cortex, which is an indicator of female reproductive ability. Actually, ovarian reserve depends on the size of follicle pool in ovarian cortex. Follicles develop in the ongoing process of folliculogenesis and follicular growth, development, maturity, apoptosis, atresia and depletion. Folliculogenesis in ovary starts from fetus and lasts throughout the whole reproductive years. With the reduced production of folliculogenesis, the quality of oocytes is subsequently compromised. The decreased folliculogenesis and oocytes quality result in the lowered fertility, which is known as the diminished ovarian reserve. It was recently reported that chemotherapy as an iatrogenic factor could lead to the decreased ovarian reserve and even premature ovarian failure (POF) by disrupting the primordial follicle pool. This review summarized the recent progress on the impact of chemotherapy on the primordial follicles, as well as the ovarian protection from chemotherapy.

Key words: Ovary, Ovarian follicle, Drug therapy, Ovarian failure, premature