关键词: 多囊卵巢综合征, RNA, 长链非编码RNA, 微阵列分析, 综述

Abstract: Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disease, but its pathogenesis is still not very clear. Long noncoding RNAs (lncRNAs) are a class of non-coding RNAs with more than 200 nucleotides in length. Some sequencing studies found the differential expression of lncRNAs in the peripheral blood leukocytes, cumulus and granulosa cells of PCOS patients, such as CTBP1-AS, steroid receptor RNA activator (SRA), lncRNA-low expression in tumor (lncRNA-LET) and growth arrest specific 5 (GAS5), etc. Further studies found that these differentially expressed lncRNAs may be involved in steroid production, steroid receptor activity, obesity and insulin resistance (IR), the proliferation, migration and apoptosis of granulosa cells, and the development of oocytes. All of these pathophysiological mechanisms are related to PCOS pathogenesis and developemnt. Here we review the research progress of lncRNAs in PCOS, in order to provide new ideas for the study and treatment of PCOS.

Key words: Polycystic ovary syndrome, RNA, long noncoding RNA, Microarray analysis, Review