关键词: F-box蛋白, 卵巢, 卵泡, 泛素化, 卵巢功能早衰, 卵巢肿瘤

Abstract: F-box proteins, a family of proteins widely distributed in the prokaryote and eukaryote, are involved in the regulation of fundamental biological progresses such as cell cycle control, apoptosis induction, cellular signal transduction, tumorigenesis, etc through ubiquitin proteasome system (UPS). Recent years, several studies have shown that there exist many kinds of F-box proteins in ovarian tissue. Disfunction of F-box proteins can result in reproductive and endocrine problems and diseases, such as follicular maldevelopment, premature ovarian failure and even ovarian cancer. With the research progress on intracellular ubiquitination, more and more mechanisms of F-box proteins related to ovarian function have been revealed, which may provide new treatment options for some ovarian diseases. This review briefly summarized the functions and research progress of F-box proteins in ovary.

Key words: F-box protein, Ovary, Ovarian follicle, Ubiquitination, Ovarian failure, premature, Ovarian neoplasms