国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2019, Vol. 38 ›› Issue (3): 206-208.

• 论著 • 上一篇    下一篇

年龄对体外受精-胚胎移植临床结局的影响

徐丽爽，陈洁，熊芳，韦玮   

  1. 214002 南京医科大学附属无锡市妇幼保健院生殖医学中心
  • 收稿日期:2019-02-25 修回日期:2019-04-15 出版日期:2019-05-15 发布日期:2019-05-16
  • 通讯作者: 韦玮，E-mail：605883733@qq.com E-mail:155330359@qq.com

Effect of Age on Clinical Outcomes of In Vitro Fertilization-Embryo Transfer

XU Li-shuang, CHEN Jie, XIONG Fang, WEI Wei   

  1. Reproductive Medicine Center, The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi 214002, China
  • Received:2019-02-25 Revised:2019-04-15 Published:2019-05-15 Online:2019-05-16
  • Contact: WEI Wei, E-mail: 605883733@qq.com E-mail:155330359@qq.com

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摘要： 目的：探讨年龄对体外受精-胚胎移植（IVF-ET）临床结局的影响。方法：回顾性分析2013年1月—2017年7月于本中心4 512例IVF-ET患者的临床结局，根据年龄分为6组：＜35岁组（3 619例，其中11例失访）、35～37岁组（479例）、38～40岁组（262例）、41～42岁组（90例）、43～44岁组（39例）和＞44岁组（23例），比较6组患者的临床妊娠率、早期流产率、晚期流产率、异位妊娠率和活产率。结果：＜35岁组临床妊娠率最高，为54.42%，随着年龄增长妊娠率逐渐下降，差异有统计学意义（P＜0.000 1）；早期流产率随年龄增长呈上升趋势（P＜0.000 1），35岁以上组明显升高（＞20%），40岁以上组高达40%；活产率随年龄增长呈下降趋势（P＜0.000 1），44岁以上女性活产率为0。结论：女性年龄是影响IVF-ET临床结局的重要因素，38岁以上不孕患者的IVF-ET临床结局较差，应尽早干预。

关键词: 受精, 体外, 胚胎移植, 年龄因素, 妊娠结局

Abstract: Objective：To investigate the effect of age on the clinical outcomes of in vitro fertilization-embryo transfer (IVF-ET). Methods: The clinical data of 4 512 infertile women who received IVF-ET in our Reproductive Medicine Center from January 2013 to July 2017 was analyzed retrospectively. All subjects were divided into six groups: younger than 35 years (3 619 cases, 11 patients were lost in follow-up), aged 35-37 years (479 cases), aged 38-40 years (262 cases), aged 41-42 years (90 cases), aged 43-44 years (39 cases), and older than 44 years (23 cases). The clinical pregnancy rate, first-trimester abortion rate, late abortion rate, ectopic pregnancy rate and live birth rate were compared among six groups. Results: There were decreases with age in the clinical pregnancy rate (P＜0.000 1), while the clinical pregnancy rate was best in the group of ＜35 years(54.42%). Meanwhile，the early abortion rate was increased significantly with age, especially in the women over 35 years (P＜0.01), and almost reached to 40% in the women more than 40 years. The live birth rate was decreased with age (P＜0.000 1), and this rate was 0 in those women aged more than 44 years. Conclusions: Age is a key factor related to the clinical outcomes of IVF-ET. The early intervention treatment should be advocated in those infertile women aged over 38 years because of the poor clinical outcomes.

Key words: Fertilization in vitro, Embryo transfer, Age factors, Pregnancy outcome