胰高血糖素样肽1受体激动剂在肥胖型PCOS不孕患者中

doi:10.12280/gjszjk.20210103

摘要/Abstract

摘要：

多囊卵巢综合征（polycystic ovary syndrome,PCOS）以高雄激素血症、稀发/无排卵、卵巢多囊样改变以及生育力下降为主要特征,是造成育龄期女性无排卵性不孕最常见的原因,且PCOS患者多伴有肥胖,而肥胖本身对女性生育力同样有负面影响。胰高血糖素样肽1（glucagon-like peptide-1,GLP-1）作为一种重要的胃肠激素,在肥胖以及PCOS进展中具有重要作用。综述肥胖/超重女性不孕以及PCOS发生机制,GLP-1在肥胖型PCOS女性中分泌模式的改变,以期为GLP-1受体激动剂（GLP-1 receptor agonists,GLP-1RA）在治疗肥胖型PCOS不孕患者中的应用提供理论支持。

关键词: 胰高血糖素样肽1, 胰高血糖素样肽-1受体, 多囊卵巢综合征, 肥胖症, 不育,女（雌）性, 生殖技术,辅助

Abstract:

Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenemia, oligo/anovulation, polycystic ovarian changes and impaired fertility. It is the most common cause of anovulatory infertility in women of childbearing age. Most of PCOS patients are accompanied by obesity, while obesity also has a negative impact on fertility. Glucagon-like peptide-1 (GLP-1) as an important gastrointestinal hormone plays an important role in the obesity and progression of PCOS. This review summarizes the mechanism of PCOS and infertility with obese/ overweight and the change of secretion pattern of GLP-1 in those PCOS women with obese. This review will provide the references that GLP-1 receptor agonists (GLP-1RA) can be used in the treatment of PCOS and infertile patients with obesity.

Key words: Glucagon-like peptide 1, Glucagon-like peptide-1 receptor, Polycystic ovary syndrome, Obesity, Infertility, female, Reproductive techniques, assisted

杨泽欣, 王俊超. 胰高血糖素样肽1受体激动剂在肥胖型PCOS不孕患者中[J]. 国际生殖健康/计划生育, 2021, 40(5): 436-440.

YANG Ze-xin, WANG Jun-chao. Potential Application of Glucagon-Like Peptide-1 Receptor Agonists in the Treatment of Polycystic Ovary Syndrome and Infertile Patients with Obesity[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(5): 436-440.

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