国际生殖健康/计划生育 ›› 2018, Vol. 37 ›› Issue (2): 154-158.

• 综述 • 上一篇    下一篇

妊娠期三酰甘油代谢的研究进展

陈梦凡,陈丹青   

  1. 310006  杭州,浙江大学医学院附属妇产科医院妇产科
  • 收稿日期:2017-12-12 修回日期:2018-01-11 出版日期:2018-03-15 发布日期:2018-03-15
  • 通讯作者: 陈丹青,E-mail:chendq@zju.edu.cn E-mail:chendq@zju.edu.cn
  • 基金资助:
    浙江省科技计划项目(2018C03010);浙江省医药卫生科技计划资助项目(WKJ-ZJ-1722)

Research Progress of Triglyceride Metabolism During Pregnancy

CHEN Meng-fan,CHEN Dan-qing   

  1. Department of Obstetrics and Gynecology,Women′s Hospital,School of Medicine,Zhejiang University,Hangzhou 310006,China
  • Received:2017-12-12 Revised:2018-01-11 Published:2018-03-15 Online:2018-03-15
  • Contact: CHEN Dan-qing,E-mail:chendq@zju.edu.cn E-mail:chendq@zju.edu.cn

摘要: 三酰甘油是人体脂质的组成部分,可被脂蛋白脂肪酶水解为游离脂肪酸和甘油并加以利用,在妊娠期参与母儿的能量供应及胎儿生长发育等多个环节。近年来研究表明,妊娠期三酰甘油水平由于受到妊娠期特有激素、胰岛素等多种因素影响,相较于非妊娠期妇女显著增加,并随妊娠期的进展而逐渐升高,同时在多种妊娠期并发症如妊娠期糖尿病、子痫前期、妊娠期肝内胆汁淤积症、早产、妊娠期急性胰腺炎等中观察到三酰甘油水平发生相应的改变。本文就三酰甘油与妊娠期糖尿病、子痫前期、妊娠期肝内胆汁淤积症等妊娠期并发症之间的关系和可能的发生机制以及监测随访等进行综述。寻求一个国际认可的、具有地区差异性的参考范围,确定有效的个体化监测及治疗指南,对妊娠期三酰甘油水平的管理具有重要意义。

关键词: 甘油三酯类, 糖尿病, 妊娠, 先兆子痫, 胆汁淤积, 肝内, 妊娠并发症, 早产

Abstract: Triglyceride as a main component of lipids in human body  can be hydrolyzed by lipoprotein lipase into free fatty acids and glycerins. Triglyceride also participates in energy supply for mother and fetus, and fetal development during pregnancy. Recently, increasing studies have shown that the level of triglyceride in pregnant women was remarkably higher than in non-pregnant women, and  that the level of triglyceride was increased with the progress of pregnancy. Interestingly, the level of triglyceride was changed in those women with gestational complications such as gestational diabetes mellitus, pre-eclampsia, intrahepatic cholestasis of pregnancy, premature delivery and gestational acute pancreatitis. This article discussed the relationships between the altered triglyceride level and gestational complications such as gestational diabetes mellitus, pre-eclampsia and intrahepatic cholestasis of pregnancy. The related mechanism and follow-up visit were also included. It is important to develop the internationally-recognized range of triglyceride with regional differences and the individualized monitoring and treatment guidelines. The management of triglyceride level during pregnancy is of great importance.

Key words: Triglycerides, Diabetes, gestational, Pre-eclampsia, Cholestasis, intrahepatic, Pregnancy complications, Premature birth