国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2016, Vol. 35 ›› Issue (1): 47-50.

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卵泡液中细胞因子与卵泡发育及妊娠结局的相关性

宝鲁日，陈秀娟，王丽岩，王煜   

  1. 010010 呼和浩特，内蒙古医科大学病理教研室（宝鲁日）；内蒙古医科大学附属医院生殖中心（陈秀娟，王丽岩，王煜）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-01-15 发布日期:2016-01-15
  • 通讯作者: 王煜

Cytokines in Follicular Fluid were Related to Follicle Development and Pregnancy Outcomes

BAO Lu-ri，CHEN Xiu-juan，WANG Li-yan，WANG Yu   

  1. Reproductive Center，Inner Mongolia Medical University Affiliated Hospital，Hohhot 010050，China（CHEN Xiu-juan，WANG Li-yan，WANG Yu）
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-01-15 Online:2016-01-15
  • Contact: WANG Yu

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摘要： 随着体外受精-胚胎移植（in vitro fertilization-embryo transfer，IVF-ET）技术水平的日益提高，卵巢微环境中调节卵母细胞发育的细胞因子的作用受到广泛关注。细胞因子作为一类具有广泛生物学活性的激素样多肽调控生殖过程，它们通过调节卵巢内分泌或旁分泌，进而影响卵泡成熟、胚胎发育及胚泡着床等环节来参与生殖调节。研究表明不孕可能与卵泡液中某些细胞因子（如血管内皮生长因子、粒细胞集落刺激因子、活性氧簇、胰岛素样生长因子、白细胞介素、白血病抑制因子等）的异常表达引发的卵泡成熟障碍有关。因而，加强卵泡液中细胞因子的研究将有助于提高IVF-ET的临床妊娠率。

关键词: 卵泡液, 细胞因子类, 卵泡, 妊娠结局

Abstract: With the increasing technology in vitro fertilization-embryo transfer（IVF-ET）, the roles of cytokines in the regulation of oocyte development in ovarian microenvironment have been widely concerned. Cytokines as a class of hormone-like peptides with comprehensive biological activity participate in the regulation of reproduction, such as the follicular development, embryo development and blastocyst implantation and others, by regulating ovarian hormones and paracrine. It was found that the abnormal expression of cytokine profile in follicular fluid, such as vascular endothelial growth factor（VEGF）, granulocyte colony stimulating factor（G-CSF）, reactive oxygen species（ROS）, insulin-like growth factor（IGF）, interleukin（IL）, and leukemia inhibitory factor（LIF） could be related to the follicular mature disturbance. The enhancing research in this area will be helpful to improve the clinical pregnancy outcomes of IVF-ET.

Key words: Follicular fluid, Cytokines, Ovarian follicle, Pregnancy outcome