国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2019, Vol. 38 ›› Issue (5): 422-425.

• 综述 • 上一篇    下一篇

长链非编码RNA与子宫内膜异位症关系的研究进展

崔粮驿，王丹丹，陈思蕾，杨清   

  1. 110000 沈阳，中国医科大学附属盛京医院妇产科
  • 收稿日期:2019-04-16 修回日期:2019-07-09 出版日期:2019-09-15 发布日期:2019-09-11
  • 通讯作者: 杨清，E-mail：yangq@sj-hospital.org E-mail:yangq@sj-hospital.org
  • 基金资助:
    中国医科大学附属盛京医院“盛京自由研究者”计划（201704）

Long Non-Coding RNA and Endometriosis

CUI Liang-yi, WANG Dan-dan, CHEN Si-lei, YANG Qing   

  1. Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang 110000, China
  • Received:2019-04-16 Revised:2019-07-09 Published:2019-09-15 Online:2019-09-11
  • Contact: YANG Qing, E-mail：yangq@sj-hospital.org E-mail:yangq@sj-hospital.org

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摘要： 长链非编码RNA（lncRNAs）是一类长度超过200个核苷酸，编码蛋白潜力较低的RNA。作为非编码RNA（ncRNAs）家族的重要成员，lncRNAs在许多重要的疾病中发挥着调控功能。子宫内膜异位症（EMs）是一种严重危害育龄期女性健康的妇科疾病，与lncRNAs关系密切。目前的研究发现，多种lncRNAs在EMs组织中存在着差异表达。进一步研究发现，lncRNAs与EMs发病的危险因素有关，也可以促进EMs的上皮间充质转化过程。同时，lncRNAs还参与对EMs细胞的增殖、迁移及细胞周期的调控，并影响EMs患者的生育能力。通过对患者血清及组织样本的筛选，学者们发现lncRNAs可以成为诊断EMs的分子标志物。现就lncRNAs与EMs关系的研究进展进行综述，以期为EMs的诊疗提供新的思路。

关键词: 长链非编码RNA, RNA, 子宫内膜异位症, 全基因组关联分析, 序列分析, 上皮间充质转化, 遗传标记

Abstract: Long non-coding RNAs (lncRNAs) are a class of RNAs that are more than 200 nucleotides in length but have low protein-coding potential. As important members of the non-coding RNA (ncRNAs) family, lncRNAs play a regulatory role in many important diseases. Endometriosis (EMs) is a gynecological disease that seriously harms the health of women of childbearing age, which is closely related to lncRNAs. The current study found that many lncRNAs are differentially expressed in EMs tissues. Further studies have found that lncRNAs are involved in the risk factors of EMs, and that lncRNAs promote the epithelial mesenchymal transition of EMs. LncRNAs are also involved in the regulation of proliferation, migration and cell cycle of EMs cells, and affect the fertility of patients with EMs. By screening patients′ serum and tissue samples, some of lncRNAs have been found to be potential molecular biomarkers for the diagnosis of EMs. In this article, the research progress of the relationship between lncRNAs and EMs was discussed, in order to provide new ideas for the diagnosis and treatment of EMs.

Key words: Long non-coding RNAs, RNA, Endometriosis, Genome-wide association studies, Sequence analysis, Epithelial-to-mesenchymal transition, Genetic markers