关键词: 多囊卵巢综合征, 维生素D, 受体, 骨化三醇, 多态现象, 遗传

Abstract: Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disease characterized by menstrual disorders, hyperandrogenism, insulin resistance and so on. Metabolic and reproductive dysfunction in PCOS patients often coexist. In recent years, studies have found that the level of vitamin D in patients with PCOS are generally lower than that in normal women. The effects of vitamin D on PCOS metabolism and reproductive dysfunction may be mediated by insulin resistance. Since vitamin D regulates gene transcription through vitamin D receptor (VDR), the effect of vitamin D on PCOS may be related to the VDR gene polymorphism, but there is ethnic difference in the correlation between VDR gene polymorphism and PCOS. The difference is more pronounced in Asian populations. The correlation between vitamin D and PCOS suggests that vitamin D supplementation may be beneficial for alleviating the metabolic abnormalities and fertility of PCOS.

Key words: Polycystic ovary syndrome, Vitamin D, Receptors, calcitriol, Polymorphism, genetic