国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2019, Vol. 38 ›› Issue (5): 407-412.

• 综述 • 上一篇    下一篇

激素及其受体调节Sertoli细胞功能的研究进展

曾毓琪，张小莉，朱可喻，袁天宜，欧阳文珺，刘悦，丁之德   

  1. 200025 上海交通大学医学院临床医学系2017级临床八年制（曾毓琪，张小莉，朱可喻，袁天宜，欧阳文珺），组织与胚胎学系（刘悦，丁之德）
  • 收稿日期:2019-05-17 修回日期:2019-07-02 出版日期:2019-09-15 发布日期:2019-09-11
  • 通讯作者: 刘悦，E-mail：liuyue@shsmu.edu.cn；丁之德，E-mail：zding@ shsmu.edu.cn E-mail:zding@shsmu.edu.cn
  • 基金资助:
    上海交通大学基础医学院RBL项目（2019002）

Hormones and Their Receptors in the Regulation of Sertoli Cell Function

ZENG Yu-qi，ZHANG Xiao-li，ZHU Ke-yu，YUAN Tian-yi，OUYANG Wen-jun，LIU Yue，DING Zhi-de   

  1. Department of Clinical Medicine，Grade 2017（ZENG Yu-qi，ZHANG Xiao-li，ZHU Ke-yu，YUAN Tian-yi，OUYANG Wen-jun），Department of Histology，Embryology，Genetics and Developmental Biology（LIU Yue，DING Zhi-de），School of Medicine，Shanghai Jiao Tong University，Shanghai 200025，China
  • Received:2019-05-17 Revised:2019-07-02 Published:2019-09-15 Online:2019-09-11
  • Contact: LIU Yue，E-mail：liuyue@shsmu.edu.cn；DING Zhi-de，E-mail：zding@shsmu.edu.cn E-mail:zding@shsmu.edu.cn

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摘要： Sertoli细胞是生精小管中唯一的体细胞，对生精过程发挥着重要作用。Sertoli细胞功能受多种激素调节，如卵泡刺激素（FSH）能调节其增殖及协助细胞间通讯（intercellular communication），且有助其形成血－睾屏障；雄激素能下调抗苗勒管激素（AMH）水平以促进Sertoli细胞发育，并维持血－睾屏障完整性；雌激素在不同剂量下可诱导Sertoli细胞凋亡与存活，并可调节水通道蛋白的表达而影响血－睾屏障等。综述各种激素及其受体对Sertoli细胞结构和功能的影响及阐明具体的分子机制，这对了解哺乳动物正常精子发生过程以及临床因精子发生障碍所致的男性不育症的治疗均有重要意义。

关键词: 激素类, 精子发生, 生殖, 塞托利细胞

Abstract: Sertoli cells, the only somatic cell in seminiferous tubule, play an important role in the process of spermatogenesis. The functions of Sertoli cells are regulated by several hormones. For example, follicle-stimulating hormone (FSH) can regulate the cell proliferation and facilitate the cellular communication, and contribute to form the blood-testis barrier (BTB) as well. Androgen can down-regulate the level of anti-Müllerian hormone (AMH) to promote the development of Sertoli cells and maintain the integrity of BTB. Estrogen can induce apoptosis and survival of Sertoli cells at different doses, and regulate the expression of aquaporin and further to affect the BTB construction. In this paper, we reviewed the influences of hormones and their receptors on the structure and function of Sertoli cells and the specific molecular mechanisms. We think that it is available for both understanding the normal processes of spermatogenesis and developing possible treatment of male infertility caused by spermatogenic disorders.

Key words: Hormones, Spermatogenesis, Reproduction, Sertoli cells