国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2019, Vol. 38 ›› Issue (6): 498-503.

• 综述 • 上一篇    下一篇

冷冻卵巢移植研究进展

王生存，李碧春   

  1. 225009 扬州大学动物科学与技术学院（王生存，李碧春）；南通大学实验动物中心（王生存）
  • 收稿日期:2018-08-16 修回日期:2019-07-29 出版日期:2019-11-15 发布日期:2019-11-15
  • 通讯作者: 王生存，E-mail：wsc@ntu.edu.cn E-mail:wsc@ntu.edu.cn
  • 基金资助:
    南通市应用基础研究科技项目（MS12015067）

Progress on the Ovarian Cryopreservation and Transplantation

WANG Sheng-cun，LI Bi-chun   

  1. College of Animal Science and Technology，Yangzhou University，Yangzhou 225009，Jiangsu Province，China（WANG Sheng-cun，LI Bi-chun）；The Laboratory Animal Center of Nantong University，NanTong 226001，Jiangsu Province，China（WANG Sheng-cun）
  • Received:2018-08-16 Revised:2019-07-29 Published:2019-11-15 Online:2019-11-15
  • Contact: WANG Sheng-cun，E-mail：wsc@ntu.edu.cn E-mail:wsc@ntu.edu.cn
  • Supported by:
     

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摘要： 哺乳动物的卵巢内有数量众多的卵细胞，是雌性生殖细胞的一个资源库。冷冻保存健康的卵巢组织，快速复苏后再原位移植到盆腔或异位移植至皮下及肾被膜等部位，有望恢复母体的生育力和维持正常激素水平。卵巢组织移植的成功与否取决于移植物的大小、局部缺血持续时间、外源性抗氧化剂和血管生成因子等因素。目前，已有少数关于人类卵巢冷冻移植并成功获得活产儿的报道，也有较多动物实验得到证实。现就冷冻卵巢移植的研究进展进行综述。

关键词: 卵巢, 冷冻, 低温保存, 移植, 生育力, 综述

Abstract: There are a large number of eggs in the ovaries of mammals, which is a resource pool of female germ cells. It is expected to restore maternal fertility, and to maintain normal levels of hormones, by the cryopreservation of healthy ovarian tissue, rapid resuscitation and then orthotopic transplantation to the pelvic cavity or heterotopic transplantation to the subcutaneous and renal capsule and other parts. The success of ovarian tissue transplantation depends on the size of graft, the duration of local ischemia, exogenous antioxidants and angiogenic factors. At present, there have been a few reports of human ovarian cryopreservation and transplantation, and the success of live births. More animal experiments confirmed this possibility. In this paper, the research progress on the ovarian cryopreservation and transplantation is reviewed.

Key words: Ovary, Freezing, Cryopreservation, Transplantation, Fertility, Review

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