国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2020, Vol. 39 ›› Issue (6): 499-503.

• 综述 • 上一篇    下一篇

复发性流产免疫相关发病因素及研究进展

李琪雁，王轶英，汪田田，魏利   

  1. 450003  郑州，河南大学人民医院，河南省人民医院妇产科（李琪雁，王轶英，魏利）；郑州大学第三附属医院妇产科（汪田田）
  • 收稿日期:2020-04-29 修回日期:2020-06-30 出版日期:2020-11-15 发布日期:2020-11-15
  • 通讯作者: 魏利，E-mail：weili196266@163.com E-mail:weili196266@163.com
  • 基金资助:
    河南省医学科技攻关计划项目（201503176，201203139）

Immune-Related Factors of Recurrent Spontaneous Abortion

LI Qi-yan，WANG Yi-ying，WANG Tian-tian，WEI Li   

  1. Department of Obstetrics and Gynecology，Henan University People′s Hospital，Henan Provincial People′s Hospital，Zhengzhou 450003，China（LI Qi-yan，WANG Yi-ying，WEI Li）；Department of Obstetrics and Gynecology，Zhengzhou University Third Affiliated Hospital，Zhengzhou 450052，China（WANG Tian-tian）
  • Received:2020-04-29 Revised:2020-06-30 Published:2020-11-15 Online:2020-11-15
  • Contact: WEI Li，E-mail：weili196266@163.com E-mail:weili196266@163.com

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摘要： 复发性流产（recurrent spontaneous abortion，RSA）一般是指孕20周前与同一性伴侣连续发生3次或3次以上的自然流产。关于RSA的发病原因，相关研究甚多，但至今不明。免疫相关因素是众多可能原因中较为重要的一环，与RSA相关的免疫异常因素不仅与母体自身免疫变化有关，还与母-胎界面免疫耐受失衡有关。因此深入研究RSA免疫相关因素对探讨RSA发病机制及新的治疗方式、改善RSA患者妊娠结局具有重要指导意义。综述RSA发病的免疫相关因素及其研究进展，以期从免疫学角度为RSA的诊治提供新思路及理论依据。

关键词: 流产, 习惯性；, 自身免疫；, 自身抗体；, 母胎免疫耐受

Abstract: Recurrent spontaneous abortion (RSA) generally refers to 3 or more consecutive miscarriages with same-sex couples before 20 weeks of gestation. The cause of RSA is still unknown, immune-related factor could be an important cause. Those factors of immune abnormality are not only related to the changes of maternal autoimmune, but also related to the imbalance of maternal-fetal immune tolerance. Further studies on RSA immune-related factors are of great significance for exploring new treatment methods of RSA and improving pregnancy outcomes in RSA patients. In this paper, the immune-related factors and progress of RSA are reviewed in order to provide new ideas for the diagnosis and treatment of RSA.

Key words: Abortion, habitual；, Autoimmunity；, Autoantibodies；, Maternal-fetal immune tolerance