国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2011, Vol. 30 ›› Issue (4): 334-337.

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瘦素在人类生殖领域的研究现状

龚 姗, 郝天羽, 张书芬   

  1. 066000 秦皇岛市第一医院妇产科（龚 姗）；济南军区总医院生殖医学中心（郝天羽，张书芬）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-07-15 发布日期:2011-07-15

Leptin in Human Reproduction

GONG San,HAO Tian-yu,ZHANG Shu-fen   

  1. Ｄｅｐａｒｔｍｅｎｔ ｏｆ Ｇｙｎｅｃｏｌｏｇｙ ａｎｄ Ｏｂｓｔｅｔｒｉｃｓ， Ｔｈｅ ＮＯ．１ Ｈｏｓｐｉｔａｌ ｏｆ Ｑｉｎｈｕａｎｇｄａｏ， Ｑｉｎｈｕａｎｇｄａｏ ０６６０００， Ｃｈｉｎａ（ＧＯＮＧ Ｓｈａｎ）； Ｇｅｎｅｒａｌ Ｈｏｓｐｉｔａｌ ｏｆ Ｍｉｌｉｔａｒｙ Ａｒｅａ， Ｊｉｎａｎ ２５００３１， Ｃｈｉｎａ （ＨＡＯ Ｔｉａｎ-ｙｕ， ＺＨＡＮＧ Ｓｈｕ-ｆｅｎ）
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-07-15 Online:2011-07-15

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摘要： 瘦素是肥胖基因编码的一种蛋白激素，具有多效性，通过与受体结合参与体内多种生物学作用。近年的研究发现，瘦素在神经内分泌的调节中起着重要的介导作用，可将营养状况信号传递给与生殖相关的中枢神经系统，与下丘脑-垂体-性腺轴功能的维持、卵泡发育、胚胎着床、多囊卵巢综合征及男性不育等生殖内分泌有一定关系。瘦素可直接或间接作用于生殖系统，从而对人类生殖内分泌代谢起到调控作用，深入研究瘦素在生殖系统的作用，将有助于揭示临床不孕不育症的发病机制，并为人类辅助生殖技术提供新的治疗思路。

关键词: 瘦素, 生殖内分泌, 多囊卵巢综合征, 辅助生殖技术, 男性不育

Abstract: Leptin, a novel molecule, is a protein hormone produced by the obesity gene. This protein and its receptor show that they play an important role in many biological action. Recent study found that leptin as a signal effects on the adequacy of nutritional status and reproductive function are thought to be mediated centrally via neurotransmitters. Leptin concentration is associated with hypothalam?-pituitary-gonad axis, follicular development, implantation, polycystic ovary syndrome and male infertility. Study leptin in the function of reproductive system will benefit to reveal the regulation of clinical infertility and provide the new rapeutic strategy for human assisted reproductive technology.

Key words: Leptin, Reproductive endocrinology, Polycystic ovary syndrome, Assisted reproductive technology, Male infertility