国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2016, Vol. 35 ›› Issue (4): 322-326.

• 综述 • 上一篇    下一篇

促性腺激素释放激素拮抗剂在体外受精-胚胎移植中的应用

刘小连，何玉洁   

  1. 030001 太原，山西医科大学第一临床医学院（刘小连）；山西医科大学第一医院生殖中心（刘小连，何玉洁）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-07-15 发布日期:2016-07-15
  • 通讯作者: 何玉洁

The Application of the GnRH Antagonist in in vitro Fertilization-Embryo Transfer

LIU Xiao-lian，HE Yu-jie   

  1. First Clinical Hospital of Shanxi Medical University，Taiyuan 030001，China（LIU Xiao-lian）；Reproductive Medicine Center，The First Hospital of Shanxi Medical University，Taiyuan 030001，China（LIU Xiao-lian，HE Yu-jie）
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-07-15 Online:2016-07-15
  • Contact: HE Yu-jie

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摘要： 辅助生殖技术（ART）中应用长方案治疗不孕症已得到临床工作者的一致认可，然而近年来促性腺激素释放激素拮抗剂（GnRHA）方案因治疗期短、安全、无“突发释放”作用并保留垂体反应性等优点，临床应用越来越广泛。对卵巢高反应患者，GnRHA方案可明显降低卵巢过度刺激综合征（OHSS）的发生风险，且对卵巢反应正常患者无显著不良影响。GnRHA对卵巢低反应患者的治疗仍处于探索研究阶段，临床治疗方案各有不同，已成为辅助生殖领域的研究热点。现对GnRHA对不同人群的不同治疗方案及其他GnRHA的衍生应用方案进行综述。

关键词: 受精, 体外, 胚胎移植, 促性腺素释放激素拮抗剂, 卵巢, 妊娠结局

Abstract: The long protocol of GnRH agonist for the ovulation induction in infertility treatment has been accepted by assisted reproductive technology (ART). However, in recent years, the GnRH antagonist has also been widely used in clinical practice due to its short-time, safety, no "flare-up" and reserved response. The GnRH antagonist protocol can significantly lower the occurrence of ovarian hyperstimulation syndrome (OHSS), while it has little undesirable influence in those patients with the normal response. The application of GnRH antagonist has also been tried in those patients with the low response. How to personalize the protocol of GnRH antagonist has been the research hotpot in ART area. We introduced the personalized protocols of GnRH antagonist for those patients with different responses and the other protocols derived from GnRH antagonist.

Key words: Fertilization in vitro, Embryo transfer, Gonadotropin-releasing hormone antagonist, Ovary, Pregnancy outcome