关键词: 妊娠初期, 流产, 人工, 投药, 直肠, 米索前列醇, 利多卡因

Abstract: Objective：To explore the ideal method on cervical dilatation for induced abortion. Methods: 300 cases of early pregnant women were randomly divided into 3 groups. Patients in group A
(lidocaine group) exposed the cervix who were injected by 1 mL lidocaine at the 3 and 9 point of the cervix,
and abortion operation started after 1 minute. Patients in group B（misoprostol group）were placed 400 滋g
misoprostol in the rectum 2 hours beforeoperation. Patients in group C（misoprostol combined with lidocaine
group）were placed 400 滋g misoprostol in the rectum and injected by 1 mL lidocaine at the 3 and 9 point of
the cervix 2 hours later, and operation started after 1 minute. Cervical dilatation，analgesia，complications，
incidence of abortion syndrome and bleeding were observed in the three groups. Results：The analgesia effect
of group C was obviously better than that of group A and group B（P＜0.01）, and the operation time was
shorter. The cervical dilation of group C was better than that of group A（P＜0.01），but there was no
significant difference from group B（P＞0.05）. There was no obvious difference among the blood loss of the
three groups （P＜0.05）. No abortion syndrome happened in groups B and C，while there was 1 case of
abortion syndrome in group A. Conclusions：Rectal administration of 400 滋g misoprostol combined with
lidocaine analgesia for induced abortion can achieve good results of cervical dilatation. Medication is simple，
effective，safe and can be widely used.

Key words: Pregnancy trimester, first, Abortion, induced, Administration, rectal, Misoprostol, Lidocaine