国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2014, Vol. 33 ›› Issue (5): 367-369.

• 综述 • 上一篇    下一篇

miR-23a和miR-27a在卵巢中的生理与病理作用

聂明月，杨晓葵   

  1. 100026 北京，首都医科大学附属北京妇产医院生殖医学科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-09-15 发布日期:2014-09-15
  • 通讯作者: 杨晓葵

Physiological and Pathological Effects of miR-23a and miR-27a in Ovary

NIE Ming-yue，YANG Xiao-kui   

  1. Department of Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital，Capital Medical University, Beijing 100026, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-09-15 Online:2014-09-15
  • Contact: YANG Xiao-kui

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摘要： 微小RNA（microRNA，miRNA）在转录后水平调控靶基因表达，因而在细胞增殖、分化、凋亡、存活及肿瘤的发生、发展中起重要作用。卵巢中存在多种miRNA的表达，miR-23a和miR-27a是miR-23a~27a~24-2家族成员，通过依赖caspase及非依赖caspase途径发挥促进凋亡的作用，且可以引发内质网应激过程。研究发现，miR-23a和miR-27a涉及卵巢卵泡发育、激素合成与分泌以及卵巢早衰、卵巢癌等卵巢相关病理过程。miRNA对卵巢功能的调控作用逐渐被揭示，对不孕症和某些卵巢疾病的创新治疗有一定帮助。就miR-23a和miR-27a在卵巢中的生理与病理作用进行综述。

关键词: 微小RNAs, 卵泡, 卵巢, 卵巢早衰, 卵巢肿瘤

Abstract: MicroRNAs（miRNAs） play important roles in many cellular events，such as proliferation, differentiation，apoptosis，survive and tumorigenesis by regulating expression of target genes at posttranscriptional level. Many miRNAs have been found in ovary, including miR-23a and miR-27a. miR-23a and miR-27a are members of the miR-23a~27a~24-2 super-family，induce apoptosis via caspase-dependent or caspase-independent pathways and endoplasmic reticulum stress. It was found that miR-23a and miR-27a were involved in many ovarian function and pathophysiology，including follicular development，hormone synthesis and secretion，premature ovarian failure and ovarian cancer. Many effects of miRNAs in ovarian function have been elucidated，which is helpful for new treatment options for sterility and other ovarian diseases. The functions of miR-23a and miR-27a in ovary were reviewed in this paper.

Key words: MicroRNAs, Follicle, Ovary, Premature ovarian failure, Ovarian neoplasms