国际生殖健康/计划生育杂志

国际生殖健康/计划生育杂志 ›› 2025, Vol. 44 ›› Issue (5): 424-428.doi: 10.12280/gjszjk.20250197

• 综述 • 上一篇    下一篇

髓样细胞触发受体-1在子痫前期中的作用

杨琪, 许茸茸, 崔红梅()   

  1. 730000 兰州，甘肃中医药大学（杨琪）; 甘肃省妇幼保健院（甘肃省中心医院）（许茸茸，崔红梅）
  • 收稿日期:2025-04-24 出版日期:2025-09-15 发布日期:2025-09-12
  • 通讯作者: 崔红梅 E-mail:cuihm@yeah.net
  • 基金资助:
    甘肃省科技计划项目(23JRRA1392)

The Role of Triggering Receptor Expressed on Myeloid Cells-1 in Preeclampsia

YANG Qi, XU Rong-rong, CUI Hong-mei()   

  1. Gansu University of Chinese Medicine, Lanzhou 730000, China (YANG Qi); Gansu Province Maternity and Child Health Hospital (Gansu Province Central Hospital), Lanzhou 730050, China (XU Rong-rong, CUI Hong-mei)
  • Received:2025-04-24 Published:2025-09-15 Online:2025-09-12
  • Contact: CUI Hong-mei E-mail:cuihm@yeah.net

RichHTML

1

PDF (PC)

2

摘要：

子痫前期（preeclampsia，PE）是一种妊娠期常见的并发症，其发病机制与免疫失衡、炎症反应和胎盘功能障碍密切相关。髓样细胞触发受体-1（triggering receptors expressed on myeloid cells-1，TREM-1）是重要的促炎受体，广泛表达于中性粒细胞和单核巨噬细胞，在多种炎性疾病中具有放大炎症反应的作用。研究发现，TREM-1在PE患者外周血和胎盘组织中表达显著升高，并可通过DNAX相关蛋白12（DNAX-associated protein 12，DAP12）、Toll样受体4（Toll-like receptor 4，TLR4）和核苷酸结合寡聚化结构域受体（nucleotide-binding oligomerization domain receptors，NLR）等信号通路激活核因子κB（nuclear factor-κB，NF-κB）、促进细胞因子释放，从而加剧炎症损伤与血管内皮功能障碍。TREM-1可能作为潜在生物标志物早期评估PE的风险和严重程度。综述TREM-1的结构、信号通路及其在PE发生发展中的可能作用机制，旨在为PE的早期诊断和靶向干预提供理论依据。

关键词: 先兆子痫, 炎症, 氧化性应激, 信号传导, 髓样细胞触发受体-1

Abstract:

Preeclampsia (PE) is a common complication during pregnancy. The pathogenesis of PE is closely related to immune imbalance, inflammatory responses, and placental dysfunction. The triggering receptors expressed on myeloid cells-1 (TREM-1) is an important pro-inflammatory receptor, widely expressed in neutrophils and mononuclear macrophages. TREM-1 plays a role in amplifying inflammatory responses in various inflammatory diseases. Studies have found that TREM-1 expression is significantly elevated in the peripheral blood and placental tissues of PE patients. It can activate nuclear factor-κB (NF-κB) and promote the release of cytokines through the multiple signaling pathways such as DNAX-associated protein 12 (DAP12), Toll-like receptor 4 (TLR4), and nucleotide-binding oligomerization domain receptors (NLRs), thereby exacerbating inflammatory damage and endothelial dysfunction. TREM-1 may also serve as a potential biomarker for the early assessment of PE risk and severity. This review focuses on the structure of TREM-1, its signaling pathways and possible mechanisms in the development of PE, aiming to provide a theoretical basis for the early diagnosis and targeted intervention of PE.

Key words: Pre-eclampsia, Inflammation, Oxidative stress, Signal transduction, Triggering receptor expressed on myeloid cells-1