国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2013, Vol. 32 ›› Issue (5): 327-329.

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内分泌异常与复发性流产

李 倩 ,梁晓燕   

  1. 510210 广州，中山大学附属第六医院生殖中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-09-15 发布日期:2013-09-15

Endocrine Abnormalities and Recurrent Spontaneous Abortion

LI Qian，LIANG Xiao-yan   

  1. Reproductive Center of the Sixth Affiliated Hospital of Sun Yat-sen Universty，Guangzhou 510210，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-09-15 Online:2013-09-15

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摘要： 复发性流产是指在妊娠20周前，连续发生2次或以上自然流产。复发性流产的病因目前尚未明确，主要包括遗传因素、解剖异常、内分泌异常、感染、免疫因素及不明原因的复发性流产。其中内分泌异常与复发性流产密切相关，无论是生殖腺分泌功能异常或其他相关内分泌腺体分泌异常，都有可能导致复发性流产的发生。从黄体功能不足、甲状腺功能异常、高催乳素血症、胰岛素抵抗及高雄激素血症等方面，探讨内分泌异常与复发性流产之间的相关性。内分泌异常会导致复发性流产，但是其具体机制仍需要进一步探索。

关键词: 流产, 习惯性, 孕酮, 甲状腺, 高催乳素血症, 胰岛素抗药性, 雄激素增多症

Abstract: The recurrent miscarriage is traditionally defined as three or more consecutive pregnancy losses before 20 weeks. The causes of recurrent spontaneous abortion are not clear，including genetic factors, uterine abnormalities，immunologic and endocrine factors，infections，and unexplained abortion. The endocrine disorders is related to recurrent miscarriage, including disorders of both reproductive glands and other glands. This article discussed the relationships between recurrent spontaneous abortion and endocrine disorders such as luteal insufficiency，thyroid dysfunction，hyperprolactinemia，insulin resistance and hyperandrogenism. However, it needs more study to understand the mechanism of recurrent miscarriage caused by endocrine abnormalities.

Key words: Abortion, habitual, Progesterone, Thyroid gland, Hyperprolactinemia, Insulin resistance, Hyperandrogenism