国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2011, Vol. 30 ›› Issue (4): 298-301.

• 综述 • 上一篇    下一篇

辅助生殖治疗中单卵双胎发生的研究进展

高瑞花, 陈雷宁, 全 松   

  1. 510515 广州，南方医科大学南方医院妇产科生殖医学中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-07-15 发布日期:2011-07-15
  • 通讯作者: 全 松

Monozygotic Twinning in Assisted Reproductive Technology

GAO Rui-hua, CHEN Lei-ning, QUAN Song   

  1. Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-07-15 Online:2011-07-15
  • Contact: QUAN Song

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摘要： 不孕不育治疗技术的广泛应用，使单卵双胎的发生率也随之增高。辅助生殖治疗中，促排卵药物的应用、透明带的损伤、胚胎培养条件、囊胚及多个胚胎移植均可导致单卵双胎的发生率明显高于自然妊娠，但具体的发生机制仍未明确，而且单卵双胎易导致双胎输血综合征等多种并发症，因此早期诊断、早期治疗对母婴预后有重要意义。近年，单卵双胎妊娠日渐受到生殖医学和产科医生的关注，现对辅助生殖治疗中影响单卵双胎发生的因素及其诊断、预后进行综述。

关键词: 双生, 单卵, 受精, 体外, 胚胎移植, 生殖技术, 辅助

Abstract: The incidence of monozygotic twinning raised after the assisted reproductive technology（ＡＲＴ） was used for infertility treatment. Although the detailed mechanism is not well?-known, the increased monozygotic twinning rate after ART may be related with ovarian stimulation, injury of zona pellucida, changes in culture media and multiple embryos transfer. Twin?-twin transfusion syndrome is the most serious complication, so it is important for monozygotic twinning to early diagnosis and early treatment. In recent years, doctors of reproductive medicine and obstetricians have paied more attention to monozygotic twinning. We reviewed the factors of the raised incidence of monozygotic twinning after ART, as well as diagnosis and prognosis of monozygotic twinning.

Key words: Twins, monozygotic, Fertilization in vitro, Embryo transfer, Reproductive techniques, assisted