国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2015, Vol. 34 ›› Issue (6): 457-461.

• 热点问题 • 上一篇    下一篇

HPV感染检测方法及相关问题

李源，向阳   

  1. 100032 北京，中国医学科学院 北京协和医学院 北京协和医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-11-15 发布日期:2015-11-15

Test Methods of HPV Infection and Related Issues

LI Yuan，XIANG Yang   

  1. Department of Obstetrics and Gynecology，Peking Union Medical College Hospital，Chinese Academy of Medical Science & Peking Union Medical College，Beijing 100032，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-11-15 Online:2015-11-15

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摘要： 宫颈癌与高危型人乳头状瘤病毒（HR-HPV）持续感染有关，HR-HPV检测已研发并用于宫颈癌筛查。在美国和欧洲至少有4种HPV检测方法得到批准：①杂交捕获2代（Hybrid Capture 2，HC2），②Cervista HPV HR和Cervista HPV 16/18，③Cobas 4800 HPV系统，④Aptima HPV和Aptima 16、18/45。各种检测方法的原理及特点有所差异，在宫颈癌筛查方案中有不同的临床指征。HR-HPV检测用于宫颈癌筛查，目的不是发现HPV感染，而是发现有宫颈上皮内瘤样变（CIN）Ⅱ+高风险的人群。将来HPV检测可能将逐渐取代细胞学成为宫颈癌的一线初筛方案。

关键词: 乳头状瘤病毒科, 宫颈肿瘤, 感染, 敏感性与特异性

Abstract: Cervical cancer is associated with the persistent high-risk human papillomavirus（HR-HPV） infection. The test methods of HR-HPV infection have been developed and applied in cervical cancer screening. Four HR-HPV detection methods have been approved in United States and Europe: ①HC2（Hybrid Capture 2）, ②Cervista HR-HPV HR and Cervista HR-HPV 16/18, ③Cobas 4800 HPV, ④Aptima HPV and Aptima 16,18/45. Each method varies in principal and technique, so the indications in the cervical cancer screening strategy are different. The HR-HPV infection detection is applied to find those women at high risk for CINⅡ+, rather than HPV infection. It is possible that the primary HR-HPV screening substitute the cytology-based screening in the future.

Key words: Papillomaviridae, Uterine cervical neoplasms, Infection, Sensitivity and specificity