国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2014, Vol. 33 ›› Issue (1): 40-43.

• 综述 • 上一篇    下一篇

代谢综合征对卵母细胞质量和早期胚胎发育的影响

张春梅，赵越，乔杰   

  1. 100191 北京大学第三医院妇产科生殖医学中心，教育部辅助生殖重点实验室，北京市生殖内分泌与辅助生殖重点实验室
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-01-15 发布日期:2014-01-15

Effects of Metabolic Syndrome on the Oocyte Quality and Early-stage Embryo Development

ZHANG Chun-mei，ZHAO Yue，QIAO Jie   

  1. Reproductive Medical Center，Department of Obstetrics and Gynecology，Peking University Third Hospital；Key Laboratory of Assisted Reproduction，Ministry of Education；Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology，Beijing 100191，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-01-15 Online:2014-01-15

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摘要： 代谢综合征是一种涉及多种内分泌代谢异常的疾病状态，与多囊卵巢综合征有许多共同的特征，其全球发病率有增加和年轻化趋势。患有代谢综合征的育龄妇女，除了心脑血管疾病、糖尿病等远期并发症发病风险增高之外，出现不孕、流产及妊娠期并发症的风险亦会增加。当前研究结果表明，在患有代谢综合征的育龄妇女中，母体异常的代谢环境可能在妊娠早期阶段即对子代产生了不良影响。综述近年有关代谢综合征对卵母细胞质量和早期胚胎发育影响的研究。

关键词: 代谢综合征X, 多囊卵巢综合征, 卵母细胞, 超重, 胰岛素抗药性

Abstract: Metabolic syndrome（MS） is characterized by various endocrine and metabolic abnormalities that are commonly seen in polycystic ovary syndrome （PCOS）. The incidence of MS is rising in the world，with a trend toward younger age. Aside from the increased risks of developing long-term complications such as cardio-cerebrovascular diseases and diabetes，those women with MS in reproductive age are prone to suffer from infertility，abortion and pregnancy complications. The abnormal maternal metabolic environment in those women with MS may exert negative effects on the offspring development at the early period of pregnancy. This article reviewed recent findings on how MS affected the oocyte quality and early-stage embryo development.

Key words: Metabolic syndrome X, Polycystic ovary syndrome, Oocytes, Overweight, Insulin resistance