国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2017, Vol. 36 ›› Issue (2): 146-149.

• 综述 • 上一篇    下一篇

来曲唑应用于多囊卵巢综合症多囊卵巢综合征患者促排卵治疗的研究进展

俞楚仪1,刘佳1,李娟2,马红霞2   

  1. 1. 广州医科大学
    2. 广州医科大学附属第一医院
  • 收稿日期:2017-01-10 修回日期:2017-02-17 出版日期:2017-03-15 发布日期:2017-03-15
  • 通讯作者: 俞楚仪 E-mail:13798183597@163.com
  • 基金资助:
    广东省科技计划项目

Application of Letrozole in Ovulation Induction Therapy for Polycystic Ovary Syndrome

  • Received:2017-01-10 Revised:2017-02-17 Published:2017-03-15 Online:2017-03-15

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摘要： 【摘?要】来曲唑（LE）为第三代芳香化酶抑制剂（Aromatase inhibitors，AIs，CYP19），为人工合成的三苯三喹类衍生物。2001年在国外首次将LE正式应用于临床促排卵治疗。多囊卵巢综合征（PCOS）是育龄期妇女常见的生殖内分泌和代谢紊乱疾病，无排卵是其主要特征，为不孕不育的直接原因之一。临床上促排卵治疗药物首选被公认的一线促排卵药物克罗米芬（CC），但因一些副作用而具有局限性。研究发现，在PCOS妇女不孕治疗中，LE可以促进子宫内膜的生长，对宫颈粘液无不利影响，给胚胎种植提供良好条件；且LE在排卵率与出生率方面优于CC，在流产率、多胎妊娠率及对胎儿的安全性上也许存在差异但目前的研究尚无统学意义。因此，在PCOS妇女不孕治疗中，LE或可取代CC成为一线的促排卵药物。

关键词: 【关键词】来曲唑, 克罗米芬, 多囊卵巢综合征, 不孕, 促排卵

Abstract: 【Abstract】 Letrozole (LE)?was?a?third-generation?aromatase inhibitor (AIs, CYP19),?which is?a kind of?artificially synthesized triphenyl quinoline derivative.?It?is?first formally used in?the?clinical treatment of ovulation induction in foreign countries in 2001.?Polycystic ovary syndrome?(PCOS) is a reproductive endocrinology and metabolic disorders commonly found in?the?women of reproductive age, with the main character of ovulation, which is one of the direct causes of infertility.Due to some side effects, there were?some limitations?to?the?clomiphene citrate (CC)?drug which?is?clinically?used?as the first choice in?the treatment of ovulation induction. The study found that?LE can promote endometrial growth?in?the?infertility treatment?of?PCOS women,?which not only has?no adverse effects on cervical mucus?but also?provides?good conditions for embryo implantation. Also,?LE?was?better than CC?in the aspect of?ovulation rate and birth rate. Perhaps, there were some differences in?abortion rate, multitle-gestation pregnancy rate and the fetal safety, but the current study?had?no?statistically significance.Therefore,LE may?replace?CC?to become?the?first-line ovulation?induction?drug?in?the?infertility treatment?of?PCOS women.

Key words: 【Keywords】Letrozole, ?Clomiphene citrate, ?Polycystic ovary syndrome, ?Infertility, Ovulation induction