Protamine and Teratozoospermia: A Short Review

doi:10.12280/gjszjk.20200238

Abstract

Abstract:

Teratozoospermia is a common type of male infertility. Protamine in human sperm, as an important protein in sperm transformation and maturity phases, is closely related to sperm morphology. The literature on protamine and teratozoospermia was reviewed. It was found that the defect in protamine molecule, the abnormal expression of protamine, and the polymorphisms of protamine gene, could all lead to abnormal morphology of human sperm and reduce the fertility of patients. Interestingly, the inverted correlation is also tenable. It was suggested that abnormal protamine in human sperm was an important factor of teratozoospermia. The definitive therapy was tried in those patients with the teratozoospermia related to abnormal protamine.

Key words: Protamines, Teratozoospermia, Infertility,male, Spermatozoa, Polymorphism,single nucleotide

CHEN Xiao-jun, JIA Yu-sen, ZHANG Zhi-jie. Protamine and Teratozoospermia: A Short Review[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(3): 216-220.

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