The Role of Sperm TsRNA in Paternal Inheritance

doi:10.12280/gjszjk.20210453

Abstract

Abstract:

TsRNA (tRNA-derived small RNA) is a class of small non-coding RNA derived from mature tRNA or pre-tRNA. Evidences show that tsRNA is an important RNA regulatory factor, which is expected to be used as a biomarker for disease prevention, diagnosis and treatment. TsRNAs expressed differently may be involved in protein synthesis, mRNA translation and transcription, and the occurrence and development of various diseases such as metabolic diseases. Moreover, tsRNA plays an important role in sperm maturation and the intergenerational inheritance of metabolic diseases. Explaining the classification of tsRNA and its functions in biology, especially in male reproduction (e.g. sperm maturation), as well as its role in paternal intergenerational inheritance, are important for protecting offspring health.

Key words: RNA,transfer, Spermatozoa, Sperm maturation, Paternal inheritance, Nutritional and metabolic diseases, tRNA-derived small RNA

XU Yu-wei, LI Wen-jing, MAO Xin-yi, MA Zhuo-yao, DING Zhi-de. The Role of Sperm TsRNA in Paternal Inheritance[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(1): 37-41.

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