Kisspeptin, Pregnancy and Related Diseases

doi:10.12280/gjszjk.20210122

Abstract

Abstract:

Kisspeptin, a neuropeptide encoded by kiss-1 gene, has been considered to inhibit tumor metastasis and regulate reproductive endocrine. Kisspeptin and its receptors are widely distributed in the brain, pituitary gland, ovary, uterus, placenta and other tissues. The expression of kisspeptin in the endometrium changes periodically, which is significantly increased in the endometrial stromal cells of the late secretion period. The concentration of kisspeptin in placenta and maternal plasma also increases sharply in the first trimester. Recent studies have shown that kisspeptin plays an important role in regulating the physiological processes of pregnancy such as decidualization, placenta formation and embryo implantation. Kisspeptin is also involved in the maintenance of glucose homeostasis during pregnancy. The abnormal level of kisspeptin is associated with pregnancy-related diseases such as recurrent abortion, preeclampsia and gestational diabetes mellitus. In this paper, the role of kisspeptin and the mechanism in the physiological pregnancy and the pregnancy-related diseases are reviewed.

Key words: Kisspeptins, Pregnancy outcome, Abortion, habitual, Pre-eclampsia, Diabetes, gestational

HAN Xin-yu, WU Tian-qiang, FENG Xiao-ling. Kisspeptin, Pregnancy and Related Diseases[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(5): 420-426.

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