Regulation of Manchette Formation and Intra-Manchette Transport

doi:10.12280/gjszjk.20210535

Abstract

Abstract:

Manchette is the structure that transiently exists in the process of spermiogenesis, mainly composed of microtubules and actins. As a specialized part of cytoskeleton in spermatids, manchette also interacts with the nuclear skeleton and centrosome. Manchette is actually a platform for the vesicles and proteins transportation during the spermatid transformation. Therefore, the malformation and/or dysfunction of the manchette may lead to the failure of flagella assembly and/or sperm head shaping, ultimately causing negative effects on male fertility. This review introduces the recent research progresses on the manchette dynamics and intra-manchette transport (IMT), especially the related regulators. Among which, the proteins regulating the formation and maintenance of manchette include hook protein family, centrosomal protein family, cilia- and flagella-associated proteins, etc. The factors participating in the IMT include the kinesin family, intraflagellar transport complex-B and so on. The more understanding of the manchette will help us to clarify the etiology and pathology of male spermatogenic disorders, and also provide us new idea for the development of male contraceptive methods.

Key words: Spermatogenesis, Cytoskeleton, Manchette, Intra-manchette transport, Dyszoospermia

WANG Xin-yi, WANG Zhi-qi, WANG Jun, XU Qin-zhou, XIA Xiao-yu. Regulation of Manchette Formation and Intra-Manchette Transport[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(2): 129-134.

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