The Role of Nrf2 in Female Reproductive System

doi:10.12280/gjszjk.20210580

Abstract

Abstract:

Nuclear factor-erythroid 2-related factor (Nrf2) is a key transcription factor which contributes to various cellular defence mechanisms and involves in timely protection against oxidative, inflammation and metabolic stress reactions. Under oxidative stress or certain chemical stimulations, Nrf2 dissociates from the chaperone protein Kelch-like ECH-associated protein 1 (Keap1), and translocates into the nucleus. Nrf2 binds to an antioxidant response element (ARE), contributes to activate a large number of downstream antioxidant target genes and then maintains the physical redox homeostasis. Importantly, the increased evidences indicate that female reproductive endocrine diseases, including polycystic ovary syndrome and endometriosis, are associated with oxidative stress. The Nrf2 pathway can protect the cells, tissues and organs related to the female reproductive system from oxidative stress by participating in regulating the antioxidant and anti-inflammatory functions in ovary, uterus, placenta and other organs. The key target of the Nrf2 pathway is expected to be used to prevent and treat female reproductive system diseases, such as polycystic ovary syndrome, endometriosis, adenomyosis and so on.

Key words: Oxidative stress, Antioxidant response elements, Female urogenital diseases, Polycystic ovary syndrome, Endometriosis, Nuclear factor-erythroid 2-related factor 2

LU Ling-jing, LI Juan, MA Hong-xia, HU Min. The Role of Nrf2 in Female Reproductive System[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(2): 134-138.

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