Ovarian Venous Angioleiomyosarcoma: A Case Report and Literature Review

doi:10.12280/gjszjk.20220313

Abstract

Abstract:

A case of ovarian venous angioleiomyosarcoma is reported. The patient was a 34-year-old young woman. The main clinical manifestations were the discovery of pelvic mass for 3 years, left lower quadrant discomfort and prolonged menstrual cycle for more than 1 month. The increases of the serum tumor markers were not obvious. The magnetic resonance imaging showed the abnormal signal mass beside the left iliac blood vessels in the left pelvis. The patient underwent laparoscopic pelvic tumor resection, right ovarian cyst excision and pelvic adhesion release under general anesthesia with tracheal intubation on April 28, 2022. The doxorubicin liposome chemotherapy was given after surgery, and the patient was followed up closely. To analyze the clinical data of this case, and to review the reported data of 12 cases will be helpful for us to improve the understanding of ovarian venous angioleiomyosarcoma.

Key words: Ovary, Leiomyosarcoma, Veins, Diagnosis, Therapy, Prognosis

LI Yu-lan, YAO Hui-ping, YANG Pan-pan, XIAO Chen-meng, MA Xue-ying, LIU Xiao, XU Fei-xue. Ovarian Venous Angioleiomyosarcoma: A Case Report and Literature Review[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(6): 468-471.

Figures/Tables 5

References 20

[1]	López-Ruiz ME, Yébenes L, Berjón A, et al. Primary Leiomyosarcoma of the Ovarian Vein: Case Report and Literature Review[J]. Int J Surg Pathol, 2017, 25(4):339-343. doi: 10.1177/1066896916679888. doi: 10.1177/1066896916679888 pmid: 27881610
[2]	Honoré LH, Robins RE, Taylor RH. Leiomyosarcoma of the right ovarian vein a case report[J]. Angiology, 1977, 28(4):285-288. doi: 10.1177/000331977702800409. doi: 10.1177/000331977702800409 pmid: 869287
[3]	Kawai K, Horiguchi H, Sekido N, et al. Leiomyosarcoma of the ovarian vein: an unusual cause of severe abdominal and flank pain[J]. Int J Urol, 1996, 3(3):234-236. doi: 10.1111/j.1442-2042.1996.tb00523.x. doi: 10.1111/j.1442-2042.1996.tb00523.x pmid: 8776624
[4]	Saigusa S, Ohi M, Inoue Y, et al. Preoperative diagnosis by three-dimensional angiography of a leiomyosarcoma arising from the left ovarian vein[J]. BMJ Case Rep, 2013, 2013:bcr2013008823. doi: 10.1136/bcr-2013-008823. doi: 10.1136/bcr-2013-008823
[5]	Cho HJ, Kim HK, Suh JH, et al. Leiomyosarcoma of the ovarian vein: a case report with radiological findings[J]. Korean J Radiol, 2008, 9(Suppl):S14-S17. doi: 10.3348/kjr.2008.9.s.s14. doi: 10.3348/kjr.2008.9.s.s14
[6]	Iannelli A, Karimdjee BS, Fabiani P, et al. Leiomyosarcoma of the ovarian vein: report of a case[J]. Int Surg, 2003, 88(1):6-8. pmid: 12731723
[7]	Chiarugi M, Pressi E, Mancini R, et al. Leiomyosarcoma of the right ovarian vein[J]. Am J Surg, 2009, 197(4):e36-e37. doi: 10.1016/j.amjsurg.2008.02.014. doi: 10.1016/j.amjsurg.2008.02.014
[8]	Tsuchiya H, Kawahara T, Kawai K, et al. A Case of Leiomyosarcoma Arising from the Ovarian Vein Preoperatively Diagnosed with Radiological Imaging[J]. Hinyokika Kiyo, 2017, 63(10):407-412. doi: 10.14989/ActaUrolJap_63_10_407. doi: 10.14989/ActaUrolJap_63_10_407 pmid: 29103254
[9]	Kim SH, Kwon HJ, Cho JH, et al. Atypical radiological features of a leiomyosarcoma that arose from the ovarian vein and mimicked a vascular tumour[J]. Br J Radiol, 2010, 83(989):e95-e97. doi: 10.1259/bjr/50917539. doi: 10.1259/bjr/50917539 URL
[10]	Tsuyoshi H, Yoshida Y, Kurokawa T, et al. Diagnosis and management of leiomyosarcoma arising from ovarian vein: case report and literature review[J]. J Obstet Gynaecol Res, 2012, 38(2):466-470. doi: 10.1111/j.1447-0756.2011.01725.x. doi: 10.1111/j.1447-0756.2011.01725.x URL
[11]	Yang SH, Chien JC, Chen CL, et al. Leiomyosarcoma of ovarian vein compression as a cause of hydronephrosis[J]. Eur J Gynaecol Oncol, 2011, 32(3):336-338. pmid: 21797130
[12]	王超, 李宝忠. 卵巢静脉平滑肌肉瘤影像表现一例[J]. 中华放射学杂志, 2017, 51(6):466-467. doi: 10.3760/cma.j.issn.1005-1201.2017.06.016. doi: 10.3760/cma.j.issn.1005-1201.2017.06.016
[13]	Rajpurohit V, Mehta P, Kothari N, et al. Leiomyosarcoma of the Right Ovarian Vein: a Case Report with Multimodality Management and Long-Term Follow-Up[J]. Indian J Surg Oncol, 2019, 10(3):523-526. doi: 10.1007/s13193-019-00936-3. doi: 10.1007/s13193-019-00936-3 URL
[14]	Hirano T, Okumura H, Maeda S, et al. Vascular leiomyosarcoma originating from the right ovarian vein: a case report and literature review[J]. Surg Case Rep, 2019, 5(1):120. doi: 10.1186/s40792-019-0679-5. doi: 10.1186/s40792-019-0679-5 pmid: 31342204
[15]	Suzuki K, Taniguchi K, Ito S, et al. Leiomyosarcoma arising from the right ovarian vein[J]. J Surg Case Rep, 2019, 2019(11): rjz302. doi: 10.1093/jscr/rjz302. doi: 10.1093/jscr/rjz302
[16]	Kozłowski M, Nowak K, Kordek A, et al. Therapeutic Management of Rare Primary Ovarian Neoplasms: Carcinosarcoma, Leiomyosarcoma, Melanoma and Carcinoid[J]. Int J Environ Res Public Health, 2021, 18(15):7819. doi: 10.3390/ijerph18157819. doi: 10.3390/ijerph18157819 URL
[17]	Kasper B, D′Ambrosio L, Davis EJ, et al. What Clinical Trials Are Needed for Treatment of Leiomyosarcoma?[J]. Curr Treat Options Oncol, 2022, 23(3):439-449. doi: 10.1007/s11864-021-00928-y. doi: 10.1007/s11864-021-00928-y URL
[18]	Devaud N, Vornicova O, Abdul Razak AR, et al. Leiomyosarcoma: Current Clinical Management and Future Horizons[J]. Surg Oncol Clin N Am, 2022, 31(3):527-546. doi: 10.1016/j.soc.2022.03.011. doi: 10.1016/j.soc.2022.03.011 pmid: 35715148
[19]	D′Ambrosio L, Touati N, Blay JY, et al. Doxorubicin plus dacarbazine, doxorubicin plus ifosfamide, or doxorubicin alone as a first-line treatment for advanced leiomyosarcoma: A propensity score matching analysis from the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group[J]. Cancer, 2020, 126(11):2637-2647. doi: 10.1002/cncr.32795. doi: 10.1002/cncr.32795 pmid: 32129883
[20]	Novotny JP, George S. Leiomyosarcoma: Does Location of Primary Help to Determine the Best Systemic Therapy Options?[J]. Curr Treat Options Oncol, 2021, 22(11):99. doi: 10.1007/s11864-021-00897-2. doi: 10.1007/s11864-021-00897-2 URL

作者	年龄（岁）	症状	位置	病理标本大小（cm）	治疗	辅助治疗	随访结果
López-Ruiz等^[1]	67	腹部不适	左侧	18×12×8	全子宫切除术+双侧附件切除术	阿霉素静脉化疗	术后17个月出现远处播散性转移
Honoré等^[2]	54	胆绞痛	右侧	4×3×3	单纯肿物切除术	外照射治疗+二次手术（清扫淋巴结）	未随访
Kawai等^[3]	61	间歇性左下腹疼痛	左侧	5.5×3×2	单纯肿物切除术	口服依托泊苷化疗	术后44个月无复发及转移
Saigusa等^[4]	78	纳差、左腹部肿物	左侧	未记录	单纯肿物切除术	未行辅助治疗	术后5个月无复发
Cho等^[5]	39	右上腹肿物	右侧	未记录	切除肿物、右肾、右侧输尿管和腹膜后组织	放疗	术后3个月出现肝脏转移
Iannelli等^[6]	50	右下腹包块	右侧	未记录	根治性肿物切除术	放疗	未随访
Chiarugi等^[7]	70	右下腹和侧腹部疼痛	右侧	7.5×3.7 ×3.5	完全切除肿物	未行辅助治疗	未随访
Tsuchiya等^[8]	54	背痛	右侧	未记录	右肾切除术、下腔静脉切除术和下腔静脉补片重建的肿瘤切除术	未行辅助治疗	术后14个月仍存活
Kim等^[9]	58	右下腹包块	右侧	未记录	腹膜后肿块切除术	未行辅助治疗	术后2个月无症状
Tsuyoshi等^[10]	49	左下腹包块	左侧	未记录	子宫和双侧附件及左侧卵巢静脉切除	吉西他滨和多西紫杉醇辅助化疗	术后22个月无复发及转移
Yang等^[11]	52	右侧腰痛	右侧	未记录	未行手术治疗	未行辅助治疗	未随访
王超等^[12]	64	腹胀、尿频伴左下腹坠痛	左侧	11.5×5.5 ×3.6	单纯肿物切除术	未行辅助治疗	未随访

作者	年龄（岁）	症状	位置	病理标本大小（cm）	治疗	辅助治疗	随访结果
López-Ruiz等^[1]	67	腹部不适	左侧	18×12×8	全子宫切除术+双侧附件切除术	阿霉素静脉化疗	术后17个月出现远处播散性转移
Honoré等^[2]	54	胆绞痛	右侧	4×3×3	单纯肿物切除术	外照射治疗+二次手术（清扫淋巴结）	未随访
Kawai等^[3]	61	间歇性左下腹疼痛	左侧	5.5×3×2	单纯肿物切除术	口服依托泊苷化疗	术后44个月无复发及转移
Saigusa等^[4]	78	纳差、左腹部肿物	左侧	未记录	单纯肿物切除术	未行辅助治疗	术后5个月无复发
Cho等^[5]	39	右上腹肿物	右侧	未记录	切除肿物、右肾、右侧输尿管和腹膜后组织	放疗	术后3个月出现肝脏转移
Iannelli等^[6]	50	右下腹包块	右侧	未记录	根治性肿物切除术	放疗	未随访
Chiarugi等^[7]	70	右下腹和侧腹部疼痛	右侧	7.5×3.7 ×3.5	完全切除肿物	未行辅助治疗	未随访
Tsuchiya等^[8]	54	背痛	右侧	未记录	右肾切除术、下腔静脉切除术和下腔静脉补片重建的肿瘤切除术	未行辅助治疗	术后14个月仍存活
Kim等^[9]	58	右下腹包块	右侧	未记录	腹膜后肿块切除术	未行辅助治疗	术后2个月无症状
Tsuyoshi等^[10]	49	左下腹包块	左侧	未记录	子宫和双侧附件及左侧卵巢静脉切除	吉西他滨和多西紫杉醇辅助化疗	术后22个月无复发及转移
Yang等^[11]	52	右侧腰痛	右侧	未记录	未行手术治疗	未行辅助治疗	未随访
王超等^[12]	64	腹胀、尿频伴左下腹坠痛	左侧	11.5×5.5 ×3.6	单纯肿物切除术	未行辅助治疗	未随访