Oxidative Stress in Ovary-Related Reproductive Disorders

doi:10.12280/gjszjk.20230028

Abstract

Abstract:

Reactive oxygen species(ROS) at the physiological level may play a role of the second messengers in signal transduction. When the body is stimulated by hypoxia, inflammatory response and others, the increased significantly level of ROS induces oxidative stress. ROS at an appropriate level promotes the first meiosis of oocytes, and induces the apoptosis of non-dominant follicles. Studies have shown that oxidative stress is closely related to hyperandrogenemia, insulin resistance, ovulation disorders and mitochondrial damage in the patients with polycystic ovary syndrome (PCOS). Controlling oxidative stress with antioxidants may be an adjunct therapy for the premature ovarian insufficiency(POI). Oxidative stress inhibits DNA methylase, which leads to DNA hypomethylation, and the abnormal expressions of microRNA and the factors related to the proliferation of ovarian cancer cells and the drug resistance. This article reviews the role of oxidative stress in ovary-related reproductive disorders such as PCOS, POI and ovarian tumors, and looks forward to the possible application of antioxidant therapy.

Key words: Oxidative stress, Polycystic ovary syndrome, Primary ovarian insufficiency

WANG Tian, MO Shao-kang, HUANG Bing-xue, WEI Lu-xiao, WANG Ling. Oxidative Stress in Ovary-Related Reproductive Disorders[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(4): 317-322.

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