Abstract: Objective： To evaluate the risk factors of intrauterine growth retardation，and to evaluate the prevention effect of multi-nutrient intervention against intrauterine growth retardation. Methods: The data was from multi?-nutrient intervention community study，which was carried out in 18 counties of 4 provinces nationwide. Then women included in the study was investigated，and followed up to record the pregnancy outcome. Results: 52 043 cases of pregnancy outcome were recorded， in which 50 769 cases were single， live births， and without malformation. According to the traditional definition， there were 134 cases of intrauterine growth retardation. The incidence rate was 0.26%. Multivariate logistic regression analysis shows that， the intrauterine growth retardation associated factors are maternal age， gestational age， fetal gender， economic status， passive smoking， drinking tea， anemia during pregnancy. Multi?-nutrient intervention reduced the incidence of intrauterine growth retardation. Conclusions: maternal age， gestational age， fetal gender， economic status， some bad habits， some disease during pregnancy is risk factors of intrauterine growth retardation. Multi?-nutrient intervention can prevent intrauterine growth retardation.

Key words: Fetal growth retardation, Risk factors, Logistic models, Nutrition therapy, Intervention studies