Research Progress of Ferroptosis and Placental Diseases

doi:10.12280/gjszjk.20220245

Abstract

Abstract:

Placenta is developed from syncytiotrophoblast cells after the differentiation of fertilized eggs. The placenta as a transient organ plays an essential role in metabolism, secretion and physical barrier in fetal growth and development. The material exchange between mother and fetus through the placenta is also a communication mechanism, which is the basis of fetal healthy development and maternal normal pregnancy. It has been suggested that ferroptosis as a unique way of cell death is related to the placental physiology and pathology. Especially in pathological pregnancy, with the decrease of antioxidant capacity and lipid peroxidation repair ability, the placenta is gradually damaged, eventually leading to placental diseases. To integrate the current literatures on ferroptosis and placental diseases, we review the effect of ferroptosis on placental diseases so as to provide the possibility of the new treatment and prevention for placental diseases.

Key words: Ferroptosis, Placenta diseases, Pre-eclampsia, Diabetes, gestational, Fetal growth retardation, Abortion, spontaneous, Premature birth

PEI Jiao-jiao, HUANG Chao-lin, CHEN Jiao. Research Progress of Ferroptosis and Placental Diseases[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(5): 425-429.

References 39

[1]	Kagan VE, Mao G, Qu F, et al. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis[J]. Nat Chem Biol, 2017, 13(1):81-90. doi: 10.1038/nchembio.2238. doi: 10.1038/nchembio.2238 pmid: 27842066
[2]	Tang D, Chen X, Kang R, et al. Ferroptosis: molecular mechanisms and health implications[J]. Cell Res, 2021, 31(2):107-125. doi: 10.1038/s41422-020-00441-1. doi: 10.1038/s41422-020-00441-1 pmid: 33268902
[3]	Kajiwara K, Beharier O, Chng CP, et al. Ferroptosis induces membrane blebbing in placental trophoblasts[J]. J Cell Sci, 2022, 135(5):jcs255737. doi: 10.1242/jcs.255737. doi: 10.1242/jcs.255737
[4]	Delhaes F, Giza SA, Koreman T, et al. Altered maternal and placental lipid metabolism and fetal fat development in obesity: Current knowledge and advances in non-invasive assessment[J]. Placenta, 2018, 69:118-124. doi: 10.1016/j.placenta.2018.05.011. doi: S0143-4004(18)30255-8 pmid: 29907450
[5]	Lee JY, Kim WK, Bae KH, et al. Lipid Metabolism and Ferroptosis[J]. Biology(Basel), 2021, 10(3):184. doi: 10.3390/biology10030184. doi: 10.3390/biology10030184
[6]	Sangkhae V, Nemeth E. Placental iron transport: The mechanism and regulatory circuits[J]. Free Radic Biol Med, 2019, 133:254-261. doi: 10.1016/j.freeradbiomed.2018.07.001. doi: 10.1016/j.freeradbiomed.2018.07.001 URL
[7]	Guo L, Zhang D, Liu S, et al. Maternal iron supplementation during pregnancy affects placental function and iron status in offspring[J]. J Trace Elem Med Biol, 2022, 71:126950. doi: 10.1016/j.jtemb.2022.126950. doi: 10.1016/j.jtemb.2022.126950 URL
[8]	Conrad M, Pratt DA. The chemical basis of ferroptosis[J]. Nat Chem Biol, 2019, 15(12):1137-1147. doi: 10.1038/s41589-019-0408-1. doi: 10.1038/s41589-019-0408-1 pmid: 31740834
[9]	Shah R, Shchepinov MS, Pratt DA. Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis[J]. ACS Cent Sci, 2018, 4(3):387-396. doi: 10.1021/acscentsci.7b00589. doi: 10.1021/acscentsci.7b00589 URL
[10]	Zhou N, Bao J. FerrDb: a manually curated resource for regulators and markers of ferroptosis and ferroptosis-disease associations[J]. Database(Oxford), 2020, 2020:baaa021. doi: 10.1093/database/baaa021. doi: 10.1093/database/baaa021
[11]	Forcina GC, Dixon SJ. GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis[J]. Proteomics, 2019, 19(18):e1800311. doi: 10.1002/pmic.201800311. doi: 10.1002/pmic.201800311
[12]	Beharier O, Kajiwara K, Sadovsky Y. Ferroptosis, trophoblast lipotoxic damage, and adverse pregnancy outcome[J]. Placenta, 2021, 108:32-38. doi: 10.1016/j.placenta.2021.03.007. doi: 10.1016/j.placenta.2021.03.007 pmid: 33812183
[13]	Murakami M, Nakatani Y, Atsumi GI, et al. Regulatory Functions of Phospholipase A2[J]. Crit Rev Immunol, 2017, 37(2/3/4/5/6):127-195. doi: 10.1615/CritRevImmunol.v37.i2-6.20. doi: 10.1615/CritRevImmunol.v37.i2-6.20
[14]	Beharier O, Tyurin VA, Goff JP, et al. PLA2G6 guards placental trophoblasts against ferroptotic injury[J]. Proc Natl Acad Sci U S A, 2020, 117(44):27319-27328. doi: 10.1073/pnas.2009201117. doi: 10.1073/pnas.2009201117 pmid: 33087576
[15]	Sun WY, Tyurin VA, Mikulska-Ruminska K, et al. Phospholipase iPLA(2)β averts ferroptosis by eliminating a redox lipid death signal[J]. Nat Chem Biol, 2021, 17(4):465-476. doi: 10.1038/s41589-020-00734-x. doi: 10.1038/s41589-020-00734-x URL
[16]	Dikalova AE, Pandey A, Xiao L, et al. Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress[J]. Circ Res, 2020, 126(4):439-452. doi: 10.1161/CIRCRESAHA.119.315767. doi: 10.1161/CIRCRESAHA.119.315767 pmid: 31852393
[17]	Yu H, Zhang Y, Liu M, et al. SIRT3 deficiency affects the migration, invasion, tube formation and necroptosis of trophoblast and is implicated in the pathogenesis of preeclampsia[J]. Placenta, 2022, 120:1-9. doi: 10.1016/j.placenta.2022.01.014. doi: 10.1016/j.placenta.2022.01.014 pmid: 35150983
[18]	Alvarez SW, Sviderskiy VO, Terzi EM, et al. NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis[J]. Nature, 2017, 551(7682):639-643. doi: 10.1038/nature24637. doi: 10.1038/nature24637 URL
[19]	Yang Y, Luo M, Zhang K, et al. Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma[J]. Nat Commun, 2020, 11(1):433. doi: 10.1038/s41467-020-14324-x. doi: 10.1038/s41467-020-14324-x
[20]	Wang L, Liu Y, Du T, et al. ATF3 promotes erastin-induced ferroptosis by suppressing system Xc[J]. Cell Death Differ, 2020, 27(2):662-675. doi: 10.1038/s41418-019-0380-z. doi: 10.1038/s41418-019-0380-z pmid: 31273299
[21]	Li Y, Feng D, Wang Z, et al. Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion[J]. Cell Death Differ, 2019, 26(11):2284-2299. doi: 10.1038/s41418-019-0299-4. doi: 10.1038/s41418-019-0299-4 pmid: 30737476
[22]	Burton GJ, Cindrova-Davies T, Yung HW, et al. HYPOXIA AND REPRODUCTIVE HEALTH: Oxygen and development of the human placenta[J]. Reproduction, 2021, 161(1):F53-F65. doi: 10.1530/REP-20-0153. doi: 10.1530/REP-20-0153 URL
[23]	Wray S, Alruwaili M, Prendergast C. HYPOXIA AND REPRODUCTIVE HEALTH: Hypoxia and labour[J]. Reproduction, 2021, 161(1):F67-F80. doi: 10.1530/REP-20-0327. doi: 10.1530/REP-20-0327 pmid: 33112773
[24]	Schoots MH, Gordijn SJ, Scherjon SA, et al. Oxidative stress in placental pathology[J]. Placenta, 2018, 69:153-161. doi: 10.1016/j.placenta.2018.03.003. doi: S0143-4004(18)30070-5 pmid: 29622278
[25]	Turco MY, Gardner L, Kay RG, et al. Trophoblast organoids as a model for maternal-fetal interactions during human placentation[J]. Nature, 2018, 564(7735):263-267. doi: 10.1038/s41586-018-0753-3. doi: 10.1038/s41586-018-0753-3 URL
[26]	Taysi S, Tascan AS, Ugur MG, et al. Radicals, Oxidative/Nitrosative Stress and Preeclampsia[J]. Mini Rev Med Chem, 2019, 19(3):178-193. doi: 10.2174/1389557518666181015151350. doi: 10.2174/1389557518666181015151350 pmid: 30324879
[27]	Guerby P, Tasta O, Swiader A, et al. Role of oxidative stress in the dysfunction of the placental endothelial nitric oxide synthase in preeclampsia[J]. Redox Biol, 2021, 40:101861. doi: 10.1016/j.redox.2021.101861. doi: 10.1016/j.redox.2021.101861 URL
[28]	Zhang H, He Y, Wang JX, et al. miR-30-5p-mediated ferroptosis of trophoblasts is implicated in the pathogenesis of preeclampsia[J]. Redox Biol, 2020, 29:101402. doi: 10.1016/j.redox.2019.101402. doi: 10.1016/j.redox.2019.101402 URL
[29]	Jones JG. Hepatic glucose and lipid metabolism[J]. Diabetologia, 2016, 59(6):1098-1103. doi: 10.1007/s00125-016-3940-5. doi: 10.1007/s00125-016-3940-5 pmid: 27048250
[30]	Zheng Y, Hu Q, Wu J. Adiponectin ameliorates placental injury in gestational diabetes mice by correcting fatty acid oxidation/peroxide imbalance-induced ferroptosis via restoration of CPT-1 activity[J]. Endocrine, 2022, 75(3):781-793. doi: 10.1007/s12020-021-02933-5. doi: 10.1007/s12020-021-02933-5 URL
[31]	Han D, Jiang L, Gu X, et al. SIRT3 deficiency is resistant to autophagy-dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting GPX4 levels[J]. J Cell Physiol, 2020, 235(11):8839-8851. doi: 10.1002/jcp.29727. doi: 10.1002/jcp.29727 pmid: 32329068
[32]	Yang XD, Yang YY. Ferroptosis as a Novel Therapeutic Target for Diabetes and Its Complications[J]. Front Endocrinol(Lausanne), 2022, 13:853822. doi: 10.3389/fendo.2022.853822. doi: 10.3389/fendo.2022.853822
[33]	Burton GJ, Jauniaux E. Pathophysiology of placental-derived fetal growth restriction[J]. Am J Obstet Gynecol, 2018, 218(2S):S745-S761. doi: 10.1016/j.ajog.2017.11.577. doi: 10.1016/j.ajog.2017.11.577
[34]	Akison LK, Nitert MD, Clifton VL, et al. Review: Alterations in placental glycogen deposition in complicated pregnancies: Current preclinical and clinical evidence[J]. Placenta, 2017, 54:52-58. doi: 10.1016/j.placenta.2017.01.114. doi: S0143-4004(17)30116-9 pmid: 28117144
[35]	Miller SL, Yawno T, Alers NO, et al. Antenatal antioxidant treatment with melatonin to decrease newborn neurodevelopmental deficits and brain injury caused by fetal growth restriction[J]. J Pineal Res, 2014, 56(3):283-294. doi: 10.1111/jpi.12121. doi: 10.1111/jpi.12121 pmid: 24456220
[36]	Zhang Y, Zhou J, Li MQ, et al. MicroRNA-184 promotes apoptosis of trophoblast cells via targeting WIG1 and induces early spontaneous abortion[J]. Cell Death Dis, 2019, 10(3):223. doi: 10.1038/s41419-019-1443-2. doi: 10.1038/s41419-019-1443-2 pmid: 30833572
[37]	Meihe L, Shan G, Minchao K, et al. The Ferroptosis-NLRP1 Inflammasome: The Vicious Cycle of an Adverse Pregnancy[J]. Front Cell Dev Biol, 2021, 9:707959. doi: 10.3389/fcell.2021.707959. doi: 10.3389/fcell.2021.707959 URL
[38]	Stefanovic V, Andersson S, Vento M. Oxidative stress-Related spontaneous preterm delivery challenges in causality determination, prevention and novel strategies in reduction of the sequelae[J]. Free Radic Biol Med, 2019, 142:52-60. doi: 10.1016/j.freeradbiomed.2019.06.008. doi: 10.1016/j.freeradbiomed.2019.06.008 URL
[39]	Li Q, Han X, Lan X, et al. Inhibition of neuronal ferroptosis protects hemorrhagic brain[J]. JCI Insight, 2017, 2(7):e90777. doi: 10.1172/jci.insight.90777. doi: 10.1172/jci.insight.90777 URL