Journal of International Reproductive Health/Family Planning

Journal of International Reproductive Health/Family Planning ›› 2011, Vol. 30 ›› Issue (3): 222-225.

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Progress in the Research of Polymorphisms in the Methylenetetrahydrofolate Reductase and Methionine Synthase Genes with Male Infertility

LIU Ling， QIAN Wei-ping   

  1. Reproductive Medicine Center of Peking University Shenzhen Hospital， Shenzhen 518036， Guangdong Province, China[LIU Ling（Currently Studying in the Medical College of Shantou University）， QIAN Wei-ping]
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-05-15 Online:2011-05-15
  • Contact: QIAN Wei-ping

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Abstract: he factors, such as susceptible genes, enviroment and nutrition, play an important role in the process of disease. Methylenetetrahydrofolate reductase（ＭＴＨＦＲ） and methionine synthase（ＭＳ） are the key enzymes in folate and homocysteine metabolism. Defect of their activities may increase the sera level of homocysteinｅ（Ｈｃｙ）， induce abnormal DNA hypomethylation, thereby various dis-orders. There are some debates on the association between the polymorphism?C677T of MTHFR gene and male infertility, while there are few reports on the association between other gene polymorphisms（MTHFR A1298C，MS A2756G） and male infertility. In this review, we focused on the research of polymorphisms in the MTHFR and MS genes and Hcy in patients with male infertility.

Key words: Methylenetetrahydrofolate reductase（ＮＡＤＰＨ２）, Polymorphism, genetic, 5-methylte-rahydrofolate-homocysteine S-methyltransferase, Cysteine, Infertility, male