Abstract: Notch signaling is an evolutionally conserved system, which generally expressed in invertebrates and vertebrates to control cell fates, including human tissues. NOTCH receptor is a member of transmenbrane receptor family. Notch pathway regulates cell differentiation, proliferation, apoptosis, as well as invasiveness and metastasis of malignant cells. It plays an important role in embryogenesis, angiogenesis and the physical accommodation of placental vessels. This review summarized the current knowledge of Notch signaling pathway enhancing the invasiveness of trophoblasts and angiogenesis of placenta.

Key words: Receptors, notch, Signal transduction, Gestational trophoblastic neoplasms