Leukemia Inhibitory Factor Related to Endometrial Receptivity

doi:10.12280/gjszjk.20220168

Abstract

Abstract:

Endometrial receptivity plays a key role in embryo implantation, and 2/3 of embryo implantation failures are due to poor endometrial receptivity. Leukemia inhibitory factor (LIF) is an important biological marker of endometrial receptivity. The expression of LIF is highly upregulated in the endometrial glandular epithelium during the implantation window. LIF participates in the regulation of signal transduction of endometrial epithelial cells during embryo implantation, which may transform the endometrium from a non-receptive state to a receptive state. Abnormal expression of LIF impaires endometrial receptivity, which is closely related to the occurrence of infertility. Studies have showed that the expression of LIF is steroid-dependent, and that the expression can also be regulated by a variety of cytokines and growth factors. This paper describes the expression of LIF, signal transduction pathway and influencing factors of LIF expression in the establishment of endometrial receptivity, embryo implantation and decidualization, providing new ideas for the diagnosis and treatment of endometrial receptivity.

Key words: Leukemia inhibitory factor, Embryo implantation, Decidua, Signal transduction, Endometrial receptivity

ZHANG Xiao-xuan, ZHAI Chao, LI Guang-can, REN Chun-e. Leukemia Inhibitory Factor Related to Endometrial Receptivity[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(4): 327-331.

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