Abstract: Objective：Characteristic of endocrinological disturbance in PCOS subgroups were explored to provide individualized treatment options. Methods： 232 PCOS patients were recruited and divided into subgroup according to their body mass index（BMI） and luteinizing hormone/follicular stimulation hormone （LH/FSH） ratio. Basal serum sexual hormone， Anti-müllerian hormone（AMH）， markers of lipid metabolism and subacute inflammation were analyzed. Results： PCOS patients with LH/FSH＜2 were characterized by significant hypothalamus-pituitary gland-ovary（HPO） axis dysfunction， and their metabolic disturbance or subacute inflammatary response was not significant. PCOS patients with BMI≥23 kg/m2 showed typical obesity， which is accompanied by metabolic disorder， and are highly vulnerable to cardiovascular diseases. Conclusions： The introduction of BMI=23 kg/m2 and LH/FSH=2 to classify PCOS patients appears to be of great value in category of PCOS phenotype， which would greatly improve the individualized treatment in clinic practice.

Key words: Polycystic ovary syndrome, Body mass index, Luteinizing hormone, Follicle stimulating hormone, Therapy