Journal of International Reproductive Health/Family Planning ›› 2012, Vol. 31 ›› Issue (2): 129-132.

• 综述 • Previous Articles     Next Articles

The Metastasis-associated MicroRNAs in Ovarian Cancer

ZHOU Xing-chen,QIU Li-hua   

  1. Department of Obstetrics and Gynecology,Shanghai Renji Hospital,School of Medicine,Shanghai Jiao Tong University, Shanghai 200001, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-03-15 Online:2012-03-15

Abstract: MicroRNAs(miRNAs), a class of small non-coding RNAs, negatively regulate the
expression of target genes at the post -transcriptional level. The tumor -associated miRNAs have been
demonstrated to act as either oncogenes or tumor suppressors. Recent studies suggested that some miRNAs
acting on target genes through various pathways, might play roles in regulating tumor metastasis in ovarian
cancer. Therefore,it is possible to find new targets for therapy of ovarian cancer by studying the effects of
miRNAs on ovarian cancer metastasis.

Key words: Ovarian neoplasms, Neoplasm invasiveness, Neoplasm metastasis, MicroRNAs