Abstract: Objective：To assess the effectiveness and safety of Placenta Hominis in treatment of premature ovarian failure of Chinese people. Methods：A systematic review and meta -analysis of the randomized/semi -randomized controlled trials was designed to study Placenta Hominis used for treatingpremature ovarian failure. Articles were searched from The Cochrane Library, All EBM Reviews, EMBASE,PUBMED, MEDLINE, CNKI, etc. RevMan 5.0.25 recommended by The Cochrane Collaboration was used toconduct this systematic review and meta -analysis. Results：Two trials including 135 patients were included.The methodological quality of two studies was low. The menses recovery rate in the group treated with PlacentaHominis combined with artificial menstrual cycle was significantly higher than that in the control group treatedwith simple artificial menstrual cycle（RR=1.47，95%CI：1.19耀1.82，P=0.0004）.The change of serum E2 levelin the group treated with Placenta Hominis combined with artificial menstrual cycle was also better than that inthe control group（WMD =原42.29，95% CI：-56.45耀-28.13，P<0.000 01）. Conclusions：In the treatment of premature ovarian failure, Placenta Hominis combined with artificial menstrual cycle hada relatively highermenses recovery rate and better serumE2 level than the control group. It can not be concluded at present thatPlacenta Hominis is better than the hormonal treatment. More evidence from the high quality, randomizedplacebo controlled trials is needed to assess the effectiveness and safety of traditional Chinese herbals, such asPlacenta Hominis, in treating premature ovarian failure.

Key words: PLACENTA HOMINIS, Ovarian failure, premature, Systematic review, China